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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Sural sensory action potential identifies diabetic peripheral neuropathy response to therapy
Muscle and Nerve, Volume 32, No. 5, Year 2005
Notification
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Description
Identifying patients with diabetic peripheral neuropathy (DPN) amenable to therapy is a challenge. To determine whether the amplitude of the sural sensory nerve action potential (sural SNAP) reflects the severity of DPN, an analysis was performed on 205 patients with DPN, identified by an abnormal vibration detection threshold (VDT), who were enrolled in a multinational clinical trial investigating ruboxistaurin (RBX) mesylate. Nerve conduction velocity and response amplitude and latency were measured and compared. VDT was significantly lower in those with preserved sural SNAPs (n = 128) than in those in whom they were absent (n = 77; 21.5 vs. 22.7 JND units, P = 0.002). Thus, preserved sural SNAP denoted less severe DPN. Logistic regression analyses evaluating baseline characteristics, HbA1c, and baseline symptom scores identified only DPN duration as a factor that might contribute to the presence of sural SNAP (P = 0.004; OR = 0.896). For patients with abnormal VDT, preserved sural SNAP identifies a patient population with less severe DPN who may respond to therapeutic intervention in clinical trials. © 2005 Wiley Periodicals, Inc.
Authors & Co-Authors
Vinik, Aaron I.
United States, Norfolk
Eastern Virginia Medical School
Bril, Vera M.
Canada, Toronto
University of Toronto
Statistics
Citations: 48
Authors: 2
Affiliations: 5
Identifiers
Doi:
10.1002/mus.20423
ISSN:
0148639X
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cross Sectional Study