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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya
AIDS, Volume 27, No. 13, Year 2013
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Description
We evaluated the University of North Carolina- Malawi Risk Screening Score (UMRSS) for detection of acute and early HIV-1 infection (AEHI) in a cohort of Kenyan MSM with approximately 8% annual HIV-1 incidence. Three components of the UMRSS (fever, diarrhea, and discordant rapid HIV tests) were also independent predictors of AEHI in our cohort. The predictive ability (area under the receiver operating characteristic curve, AUC) of the UMRSS was 0.79. A cohort-derived risk score consisting of six characteristics (fever, diarrhea, discordant rapid HIV tests, fatigue, age <30 years, and symptomatic sexually transmitted disease) had a higher AUC of 0.85. Screening for AEHI will have substantial transmission prevention benefits. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3748854/bin/aids-27-2163-s001.pdf
Authors & Co-Authors
Wahome, Elizabeth W.
Kenya, Kilifi
Centre for Geographic Medicine Research
Fegan, Greg
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
Nuffield Department of Medicine
Okuku, Haile Selassie
Kenya, Kilifi
Centre for Geographic Medicine Research
Mugo, Peter Mwangi
Kenya, Kilifi
Centre for Geographic Medicine Research
Price, Matt A.
United States, New York
International Aids Vaccine Initiative
Mwashigadi, Grace Mkanjala
Kenya, Kilifi
Centre for Geographic Medicine Research
Thiong'O, Alexander N.
Kenya, Kilifi
Centre for Geographic Medicine Research
Graham, Susan Marie
Kenya, Kilifi
Centre for Geographic Medicine Research
United States, Seattle
University of Washington
Sanders, Eduard Joachim
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 84
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/QAD.0b013e3283629095
e-ISSN:
14735571
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Kenya
Malawi