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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma
Bioorganic and Medicinal Chemistry Letters, Volume 20, No. 1, Year 2010
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Description
Synthesis of a new series of diarylureas and amides having pyrrolo[3,2-b]pyridine scaffold is described. Their in vitro antiproliferative activity against human melanoma cell line A375 and HS 27 human fibroblast cell line was tested and the effect of substituents on the pyrrolo[3,2-b]pyridine was investigated. The newly synthesized compounds, except meta-substituted derivatives (Ij-k and Iv-w), generally showed superior or similar activity against A375 to Sorafenib. Among all of these derivatives, compounds Ir and It having 5-benzylamide substituted 4′-amide moieties showed the most potent antiproliferative activity against A375. © 2009.
Authors & Co-Authors
Jung, Myung-ho
South Korea, Seoul
Korea Institute of Science and Technology
El-Gamal, Mohammed I.
South Korea, Seoul
Korea Institute of Science and Technology
Sim, Taebo
South Korea, Seoul
Korea Institute of Science and Technology
Lee, So-ha
South Korea, Seoul
Korea Institute of Science and Technology
Hong, Jun-hee
South Korea, Gwangju
Chosun University
Choi, Junghoon
South Korea, Seoul
Hanyang University
Yoo, Kyung-ho
South Korea, Seoul
Korea Institute of Science and Technology
Oh, Chang-hyun
South Korea, Seoul
Korea Institute of Science and Technology
Statistics
Citations: 37
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.bmcl.2009.08.005
ISSN:
0960894X