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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma Lipids and Lipoproteins in Friedreich's Ataxia and Familial Spastic Ataxia — Evidence for an Abnormal Composition of High Density Lipoproteins
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Volume 5, No. 1, Year 1978
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Description
A systematic study of plasma lipids and lipoproteins was carried out in II cases of Friedreich's ataxia and 6 cases of familial spastic ataxia (Charlevoix-Saguenay disease) using II healthy normolipidemic volunteers of comparable age and sex as controls. No differences were noted in the fatty acid profile of the total lipid fraction, in the total cholesterol and phospholipids or in the percentage distribution of the individual phospholipid classes. The triglycerides were significantly higher in Friedreich's ataxia, but remained within the normal range. Although no systematic abnormalities could be detected in the electrophoretic pattern of plasma lipoproteins or in the apolipoprotein profile on polyacrylamide gel electrophoresis, major differences were found in the high density lipoprotein (HDL) fraction. Their total amount was reduced and their composition was abnormal in both neurological diseases. In Friedreich patients, the relative proportion of cholesterol and triglycerides was increased while the relative protein content was greatly reduced. In Charlevoix disease, a similar abnormality was seen except for the excess of triglycerides. The proportion of phospholipids in HDL was the same in the three groups of patients. In addition, the low density lipoprotein (LDL) fraction was slightly reduced in both diseases. This anomaly of the HDL fraction could indicate that the HDL apolipoprotein moiety has a greater affinity for cholesterol and triglycerides in Friedreich's ataxia than its normal counterpart. © 1978, Canadian Neurological Sciences Federation. All rights reserved.
Authors & Co-Authors
Huang, Yungsheng
Canada, Quebec
Chu de Québec-université Laval
Barbeau, Andrã©
Canada, Quebec
Chu de Québec-université Laval
Bouchard, Jean Pierre
Canada, Quebec
Chu de Québec-université Laval
Davignon, Jean
Canada, Quebec
Chu de Québec-université Laval
Statistics
Citations: 40
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1017/S0317167100024951
ISSN:
03171671