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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: A cohort study in the Gambia
PLoS ONE, Volume 7, No. 6, Article e39213, Year 2012
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Description
Objective: The factors associated with the development of immune reconstitution inflammatory syndrome in HIV patients commencing antiretroviral therapy have not been fully elucidated. Using a longitudinal study design, this study addressed whether alteration in the levels of T regulatory cells contributed to the development of IRIS in a West African cohort of HIV-1 and HIV-2 patients. Seventy-one HIV infected patients were prospectively recruited to the study and followed up for six months. The patients were categorized as IRIS or non-IRIS cases following published clinical guidelines. The levels of T regulatory cells were measured using flow cytometry at baseline and all follow-up visits. Baseline cytokine levels of IL-2, IL-6, IFN-γ, TNF-α, MIP-1β, IL-1, IL-12, IL-13, and IL-10 were measured in all patients. Results: Twenty eight percent of patients (20/71) developed IRIS and were predominantly infected with HIV-1. Patients developing IRIS had lower nadir CD4 T cells at baseline (p = 0.03) and greater CD4 T cell reconstitution (p = 0.01) at six months post-ART. However, the development of IRIS was not influenced by the levels of T regulatory cells. Similarly, baseline cytokine levels did not predict the onset of IRIS. Conclusion: The development of IRIS was not associated with differences in levels of T regulatory cells or baseline pro-inflammatory cytokines. © 2012 Zaidi et al.
Authors & Co-Authors
Zaidi, Irfan
Gambia
Medical Research Council Unit uk
Peterson, Kevin L.
Gambia
Medical Research Council Unit uk
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Jeffries, David J.
Gambia
Medical Research Council Unit uk
Whittle, Hilton C.
Gambia
Medical Research Council Unit uk
de Silva, Thushan I.
Gambia
Medical Research Council Unit uk
United Kingdom, Oxford
John Radcliffe Hospital
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
John Radcliffe Hospital
Jaye, Assan
Gambia
Medical Research Council Unit uk
De-Jong, Bouke Catherine
Gambia
Medical Research Council Unit uk
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
United States, New York
New York University
Statistics
Citations: 18
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0039213
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Gambia