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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
HIV-1 subtypes and recombinants in the Republic of Congo
Infection, Genetics and Evolution, Volume 6, No. 5, Year 2006
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Description
To document the actual genetic diversity of HIV-1 strains in the Republic of Congo, 114 HIV-1 positives persons were sampled in 2003 and 2004 after their informed consent. They were attending the teaching hospital, the reference health center in Makelekele, Brazzaville and the regional hospital centers in Pointe-Noire, Gamboma and Ouesso. A total of 104 samples were genetically characterized by direct sequencing of the p24 gag region and 80 were also subtyped in the V3-V5 env region. The genetic subtype distribution of the Congolese strains showed the predominance of subtype A (36.5% and 32.5% in gag and env, respectively) and G (30.8% and 21.25%), whereas subtype D strains represented 12.5% and 15%. Subtypes C, F, H, J, K and the CRFs-01, -02, -05 -06, and also the recently characterized CRF18 were seen at lower rates. Finally, 4.8% (gag) and 6.25% (env) of the strains could not be classified. Moreover, a high intra-subtype diversity was observed in our study. Among 70 strains which have been characterized in the two genomic regions, 14 (20%) appeared to be unique recombinants. These data show a high genetic variability in the Republic of Congo, where all the subtypes have been documented together with certain subsubtypes and several CRFs. © 2006 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Niama, Fabien Roch
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Congo
National Laboratory of Public Health of Congo
Touré-Kâne, Coumba
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Vidal, Nicole
France, Montpellier
Ird Centre de Montpellier
Obengui, Pani
Congo, Brazzaville
Centre Hospitalier et Universitaire de Brazzaville
Bikandou, Blaise
Congo
National Laboratory of Public Health of Congo
Ndoundou-Nkodia, Marie Yvonne
Congo
National Laboratory of Public Health of Congo
Montavon, Céline
France, Montpellier
Ird Centre de Montpellier
Diop-Ndiaye, Halimatou
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Mombouli, Jean Vivien
Congo
National Laboratory of Public Health of Congo
Mokondzimobe, Etienne
Congo
National Laboratory of Public Health of Congo
Gaye-Diallo, Aïssatou
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Delaporte, Éric
France, Montpellier
Ird Centre de Montpellier
Parra, Henri Joseph
Congo
National Laboratory of Public Health of Congo
Peeters, Martine F.
France, Montpellier
Ird Centre de Montpellier
Mboup, Souleymane
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Statistics
Citations: 60
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.1016/j.meegid.2005.12.001
ISSN:
15671348
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Congo