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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Polymorphism in the STAT6 gene encodes risk for nut allergy
Genes and Immunity, Volume 3, No. 4, Year 2002
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Description
Nut allergy is an important and potentially life threatening food allergy with a prevalence of one in 150 children in the UK population. STAT6 (signal transducer and activator of transcription) is an important molecule in the induction and regulation of an allergic response, which maps to chromosome 12q in a region previously linked with total serum IgE concentration and atopy in different populations. We have examined the frequency of a single nucleotide polymorphism (SNP) in the 3′ UTR region of STAT6 gene in 71 UK Caucasoid patients diagnosed with nut allergy and 45 atopic patients without nut allergy using PCR-RFLP and compared these with 184 UK healthy controls. The STAT6 G allele frequency was significantly increased in nut allergy patients compared with blood donor controls (P < 0.0001, OR=2.9, 95% CI: 1.7-4.9), which was under a recessive model (GG vs GA+AA, P=0.0001, OR=3.2, 95% CI: 1.7-5.8) but not in atopic patients without nut allergy. The G allele was most frequent in the severe cases and GG homozygosity was associated with the increased risk of severe reaction (OR=3.9, 95% CI: 1. 9-8.3). We conclude that STA T6 3′ UTR polymorphism is associated with susceptibility and severity in nut allergic patients in our population. © 2002 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Mohammad-Amoli, Mahsa Mohammad
United Kingdom, Manchester
School of Medical Sciences
Hand, S.
United Kingdom, Merthyr Tydfil
Prince Charles Hospital
Hajeer, Ali H.
Saudi Arabia, Riyadh
King Fahad National Guard Hospital
Jones, K. P.
United Kingdom, Cardiff
Cardiff Metropolitan University
Rolf, S.
United Kingdom, Cardiff
Cardiff Metropolitan University
Sting, C.
United Kingdom, Llandough
University Hospital Llandough
Davies, B. H.
United Kingdom, Llandough
University Hospital Llandough
Ollier, Bill E.R.
United Kingdom, Manchester
School of Medical Sciences
Statistics
Citations: 91
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1038/sj.gene.6363872
ISSN:
14664879
Research Areas
Food Security
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study