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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: Association with toll-like receptor 4 expression and plasma levels of interleukin 8
Digestive Diseases and Sciences, Volume 56, No. 5, Year 2011
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Description
Background: Experimental and clinical studies suggest an association between small intestinal bacterial overgrowth (SIBO) and nonalcoholic steatohepatitis (NASH). Liver injury and fibrosis could be related to exposure to bacterial products of intestinal origin and, most notably, endotoxin, including lipopolysaccharide (LPS). Aim: To compare the prevalence of SIBO and its relationships to LPS receptor levels and systemic cytokines in NASH patients and healthy control subjects. Methods: Eighteen NASH patients (eight males) and 16 age-matched and gender-matched healthy volunteers were studied. SIBO was assessed by the lactulose breath hydrogen test (LHBT), plasma lipopolysaccharide binding protein (LBP) levels by ELISA, and expression (as a percentage) of TLR-2 and 4 on CD14-positive cells by flow cytometry. Pro-inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) were measured in plasma. Results: SIBO was more common in NASH patients than control subjects (77.78% vs. 31.25%; P < 0.0001). LBP levels and TLR-2 expression were similar in both groups, TLR-4/MD-2 expression on CD14 positive cells was higher among NASH patients: expression, mean ± SEM, NASH vs. control: 20.95 ± 2.91% vs. 12.73 ± 2.29%, P < 0.05. Among the examined cytokines, only IL-8 levels were significantly higher in patients than control (P = 0.04) and correlated positively with TLR-4 expression (r = 0.5123, P = 0.036). Conclusion: NASH patients have a higher prevalence of small intestinal bacterial overgrowth which is associated with enhanced expression of TLR-4 and release of IL-8. SIBO may have an important role in NASH through interactions with TLR-4 and induction of the pro-inflammatory cytokine, IL-8. © 2011 Springer Science+Business Media, LLC.
Authors & Co-Authors
Shanab, Ahmed Abu
Ireland, Cork
University College Cork
Scully, Paul C.
Ireland, Cork
University College Cork
Crosbie, Órla M.
Ireland, Cork
Cork University Hospital
Buckley, Martin J.M.
Ireland, Cork
Mercy University Hospital
O'Mahony, Liam
Switzerland, Davos
Swiss Institute of Allergy and Asthma Research
Shanahan, Fergus
Ireland, Cork
University College Cork
Gazareen, Sanaa Sayed
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Murphy, Eileen F.
Ireland, Cork
University College Cork
Quigley, Eamonn M.M.
Ireland, Cork
University College Cork
Ireland, Cork
Cork University Hospital
Statistics
Citations: 169
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1007/s10620-010-1447-3
ISSN:
01632116
Research Areas
Violence And Injury
Study Design
Cross Sectional Study