Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population
Diabetes and Metabolism, Volume 35, No. 1, Year 2009
Notification
URL copied to clipboard!
Description
Aim: The ectonucleotide pyrophosphatase/phosphodiesterase 1 enzyme (ENPP1), which downregulates insulin signaling by inhibiting insulin-receptor tyrosine kinase activity, is encoded by the ENPP1 gene. A common functional ENPP1 K121Q polymorphism has been suggested to contribute to insulin resistance, obesity and type 2 diabetes (T2D) in various ethnic groups. For this reason, we assessed the association between the ENPP1 K121Q polymorphism in T2D and obesity phenotypes in the Moroccan population. Methods: Using LightCycler® technology, we genotyped the ENPP1 K121Q polymorphism in 503 subjects with T2D and 412 normoglycaemic individuals. Results: There was no evidence of an association between ENPP1 K121Q and T2D in either an additive (P = 0.99) or recessive mode of inheritance (P = 0.47). However, the Q121 variant was significantly more frequent in obese than in non-obese subjects after adjusting for age, gender and T2D status. We observed genetic heterogeneity between obese and non-obese T2D patients (P = 0.02). The K121Q polymorphism was associated with T2D in the presence of obesity in both additive (1.55 [95% CI 1.16-2.07]; P = 0.003) and recessive (2.31 [95% CI 1.34-3.97]; P = 0.002) modes of inheritance. Conclusion: Although there was no evidence of an association between the ENPP1 K121Q variant and the general phenotype of T2D, we did find an association with adult obesity and T2D. The Q121 allele frequency in Morocco is 37.3%, placing it between European Caucasians (15%) and Black Africans (79%). This study is the first to report an association between K121Q and metabolic diseases in the Moroccan population. © 2008 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
El Achhab, Youness
Morocco, Fez
Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah
Morocco, Fez
Faculté Des Sciences Dhar el Mahraz, Université Sidi Mohamed Ben Abdellah
Meyre, David
France, Lille
Institut Pasteur de Lille
Bouatia-Naji, Nabila
France, Lille
Institut Pasteur de Lille
Berraho, Mohamed Amine
Morocco, Fez
Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah
Deweirder, Marianne
France, Lille
Institut Pasteur de Lille
Vatin, Vincent
France, Lille
Institut Pasteur de Lille
Delplanque, Jérôme
France, Lille
Institut Pasteur de Lille
Serhier, Zineb
Morocco, Fez
Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah
Lyoussi, Badiâa
Morocco, Fez
Faculté Des Sciences Dhar el Mahraz, Université Sidi Mohamed Ben Abdellah
Nejjari, Chakib
Morocco, Fez
Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah
Froguel, Philippe
France, Lille
Institut Pasteur de Lille
United Kingdom, London
Hammersmith Hospital
Chikri, Mohamed
Morocco, Fez
Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah
Statistics
Citations: 29
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.diabet.2008.06.005
ISSN:
12623636
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Morocco