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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The VIZIER project: Preparedness against pathogenic RNA viruses
Antiviral Research, Volume 78, No. 1, Year 2008
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Description
Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Coutard, Bruno
Unknown Affiliation
Gorbalenya, Alexander E.
Unknown Affiliation
Snijder, Eric J.
Unknown Affiliation
Leontovich, A. M.
Unknown Affiliation
Poupon, A.
Unknown Affiliation
De-Lamballerie, Xavier Nicolas
Unknown Affiliation
Charrel, Remi N.
Unknown Affiliation
Gould, Ernest Andrew
Unknown Affiliation
Günther, Stephan
Unknown Affiliation
Norder, Heléne
Unknown Affiliation
Klempa, Boris
Unknown Affiliation
Bourhy, Hervé
Unknown Affiliation
Rohayem, J.
Unknown Affiliation
L'hermite, E.
Unknown Affiliation
Nordlund, P.
Unknown Affiliation
Stuart, David Ian
Unknown Affiliation
Owens, Raymond
Unknown Affiliation
Grimes, Jonathan M.
Unknown Affiliation
Tucker, P. A.
Unknown Affiliation
Bolognesi, M.
Unknown Affiliation
Mattevi, A.
Unknown Affiliation
Coll, Miquel
Unknown Affiliation
Jones, Thomas Alwyn
Unknown Affiliation
Åqvist, J.
Unknown Affiliation
Unge, T.
Unknown Affiliation
Hilgenfeld, Rolf
Unknown Affiliation
Bricogne, G.
Unknown Affiliation
Neyts, Johan H.
Unknown Affiliation
La Colla, Paolo
Unknown Affiliation
Puerstinger, G.
Unknown Affiliation
Gonzalez, J. P.
Unknown Affiliation
Leroy, Éric Maurice
Unknown Affiliation
Cambillau, Christian
Unknown Affiliation
Romette, J. L.
Unknown Affiliation
Canard, Bruno
Unknown Affiliation
Statistics
Citations: 35
Authors: 35
Affiliations: 27
Identifiers
Doi:
10.1016/j.antiviral.2007.10.013
ISSN:
01663542
Research Areas
Cancer
Genetics And Genomics