Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women
AIDS Research and Therapy, Volume 7, Article 34, Year 2010
Notification
URL copied to clipboard!
Description
Background: Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.Methods: Cross-sectional study of 824 (218 HIV-negative, 606 HIV+) Rwandan women. Body composition by body impedance analysis, CD4 count, and fasting serum total cholesterol (total-C), triglycerides (TG) and high-density lipoprotein (HDL) levels were measured. Low-density lipoprotein (LDL) was calculated from Friedewald equation if TG < 400 and measured directly if TG ≥ 400 mg/dl.Results: BMI was similar in HIV+ and -negative women, < 1% were diabetic, and HIV+ women were younger. In multivariate models LDL was not associated with HIV-serostatus. HDL was lower in HIV+ women (44 vs. 54 mg/dL, p < 0.0001) with no significant difference by CD4 count (p = 0.13). HIV serostatus (p = 0.005) and among HIV+ women lower CD4 count (p = 0.04) were associated with higher TG. BMI was independently associated with higher LDL (p = 0.01), and higher total body fat was strongly associated with higher total-C and LDL. Framingham risk scores were < 2% in both groups.Conclusions: In this cohort of non-obese African women HDL and TG, but not LDL, were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular (CV) events in women, this HIV-associated difference may confer increased risk for CV disease in HIV-infected women. © 2010 Anastos et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Anastos, Kathryn M.
United States, New York
Montefiore Medical Center
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Ndamage, François
Rwanda, Kigali
Trac Plus - Center for Treatment and Research on Aids
Lu, Dalian
United States, New York
Analytic Solutions, Llc
Cohen, Mardge H.
United States, Chicago
John H. Stroger, Jr. Hospital of Cook County
Shi, Qiuhu
United States, Valhalla
New York Medical College
Lazar, Jason M.
United States, New York
Suny Downstate Health Sciences University
Bigirimana, Venerand
Rwanda, Kigali
King Faisal Hospital
Mutimura, Eugene
Rwanda, Butare
University of Rwanda
Statistics
Citations: 20
Authors: 8
Affiliations: 9
Identifiers
Doi:
10.1186/1742-6405-7-34
ISSN:
17426405
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female