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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Molecular epidemiology of HIV type 1 in Ukraine: Birthplace of an epidemic
AIDS Research and Human Retroviruses, Volume 22, No. 8, Year 2006
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Description
During the 1990s, HIV-1 spread rapidly through drug networks in Ukraine and from there throughout the former Soviet Union. To examine the origins of this epidemic, the genetics of HIV-1 in Ukraine were studied. Proviral DNA from PBMC was extracted and PCR amplified. Part of pol and nearly full genomes of HIV-1 were sequenced and characterized. The predominant genetic form in 163 strains was subtype A (66%), followed by subtypes B (30%), C (2%), D (1%), and a new AB recombinant form (1%). HIV strains from Kiev were diverse having subtypes A, B, C, and D. In Crimea, Donetsk, Poltava, and Odessa, however, the strains jwere overwhelmingly subtype A, while in Nikolaev subtype B predominated. After the near simultaneous introduction of subtypes A and B in Ukraine, subtype B remained where it was introduced while subtype A spread widely, creating the fastest growing epidemic in the world. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Saad, Magdi Darwish
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, New York
U.s. Naval Medical Research Unit No. 3
Shcherbinskaya, Alla M.
Ukraine, Kyiv
National Academy of Medical Sciences of Ukraine
Nadai, Yuka
United States, Rockville
Hjf
Kruglov, Yuri V.
Ukraine, Kyiv
National Academy of Medical Sciences of Ukraine
Antonenko, Svietlana V.
Ukraine, Kyiv
National Academy of Medical Sciences of Ukraine
Lyullchuk, Mariya G.
Ukraine, Kyiv
National Academy of Medical Sciences of Ukraine
Kravchenko, Olga N.
Ukraine, Kyiv
National Academy of Medical Sciences of Ukraine
Earhart, Kenneth C.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Sánchez, José Luís Palacio
United States, Rockville
Hjf
Birx, Deborah L.
United States, Silver Spring
Walter Reed Army Institute of Research
Carr, Jean Kirkland
United States, Silver Spring
Walter Reed Army Institute of Research
Statistics
Citations: 54
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1089/aid.2006.22.709
ISSN:
08892229
Research Areas
Genetics And Genomics
Infectious Diseases