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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Albumin, transferrin and the thyroxine-binding prealbumin/retinol-binding protein (TBPA-RBP) complex in assessment of malnutrition
Clinica Chimica Acta, Volume 63, No. 1, Year 1975
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Description
A comparative study of the level of 4 plasma proteins in malnutrition shows that albumin has low sensitivity, transferrin has intermediate and the TBPA-RBP complex has the highest sensitivity to an alteration in the nutritional status. According to protein and/or iron deficiency, the synthesis of transferrin seems to be submitted to contradictory impulses which partially invalidates this test as a reliable index for estimating protein depletion alone. On the contrary, the components of the TBPA-RBP complex respond together and in a parallel direction to protein deficiency. The high degree of sensitivity of TBPA and RBP to an inadequate protein intake is apparently related to their rapid turnover rate and to their unusual richness in tryptophan, which is known to play a key role in the control of protein synthesis. Measurement of TBPA (or RBP) is proposed as a method for the detection of pre-kwashiorkor and early marasmus. © 1975.
Authors & Co-Authors
Ingenbleek, Yves
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Belgium, Louvain-la-neuve
Université Catholique de Louvain
Van Den Schrieck, Henry George
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Belgium, Louvain-la-neuve
Université Catholique de Louvain
de Nayer, Philippe
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Belgium, Louvain-la-neuve
Université Catholique de Louvain
de Visscher, Michel G.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Belgium, Louvain-la-neuve
Université Catholique de Louvain
Statistics
Citations: 327
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/0009-8981(75)90379-4
ISSN:
00098981
Research Areas
Food Security