Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice
Nature Genetics, Volume 43, No. 6, Year 2011
Notification
URL copied to clipboard!
Description
Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people. Although 4 million people are bilaterally blind from ACG, the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High intraocular pressure traditionally was suggested to result from the iris blocking or closing the angle of the eye, thereby limiting aqueous humor drainage. Eyes from individuals with ACG often have a modestly decreased axial length, shallow anterior chamber and relatively large lens, features that predispose to angle closure. Here we show that genetic alteration of a previously unidentified serine protease (PRSS56) alters axial length and causes a mouse phenotype resembling ACG. Mutations affecting this protease also cause a severe decrease of axial length in individuals with posterior microphthalmia. Together, these data suggest that alterations of this serine protease may contribute to a spectrum of human ocular conditions including reduced ocular size and ACG. © 2011 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Nair, K. Saidas
United States, Chevy Chase
Howard Hughes Medical Institute
Hmani-Aifa, Mounira
Tunisia, Sfax
University of Sfax
Ali, Zain Belhaj
United States, Chevy Chase
Howard Hughes Medical Institute
Kearney, Alison L.
United States, Chevy Chase
Howard Hughes Medical Institute
MacAlinao, Danilo G.
United States, Chevy Chase
Howard Hughes Medical Institute
Cosma, Ioan M.
United States, Chevy Chase
Howard Hughes Medical Institute
Bouassida, Walid
Tunisia, Sfax
Chu Habib Bourguiba
Hakim, Bochra
Tunisia, Sfax
University of Sfax
BenZina, Zeineb
Tunisia, Sfax
Chu Habib Bourguiba
Soto, Ileana
United States, Chevy Chase
Howard Hughes Medical Institute
Söderkvist, Peter
Sweden, Linkoping
Linköpings Universitet
Howell, Gareth R.
United States, Chevy Chase
Howard Hughes Medical Institute
Smith, Richard S.
United States, Chevy Chase
Howard Hughes Medical Institute
Ayadi, Hammadi
Tunisia, Sfax
University of Sfax
John, Simon W.M.
United States, Chevy Chase
Howard Hughes Medical Institute
United States, Boston
Tufts University School of Medicine
Statistics
Citations: 97
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1038/ng.813
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Disability
Genetics And Genomics
Health System And Policy