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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Molecular and genomic typing for tuberculosis surveillance: A survey study in 26 European countries
PLoS ONE, Volume 14, No. 3, Article e0210080, Year 2019
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Description
Background Molecular typing and whole genome sequencing (WGS) information is used for (inter-) national outbreak investigations. To assist the implementation of these techniques for tuberculosis (TB) surveillance and outbreak investigations at European level there is a need for inter-country collaboration and standardization. This demands more information on molecular typing practices and capabilities of individual countries. We aimed to review the use of molecular/genomic typing for TB surveillance in European Union and European Economic Area countries in 2016; assess its public health value; and collect experiences on typing data use for cross-border cluster investigations. Method A web-based questionnaire was provided to all TB National Focal Points. The questionnaire consisted of three parts: i) Use and integration of molecular and genomic typing data into TB surveillance; ii) Cross-border cluster investigation and international collaboration, and iii) Perception and evaluation of public health benefits of molecular and genomic typing for TB surveillance. Results Of 26 responding countries, 20 used molecular typing for TB surveillance, including nine applying WGS. The level of integration into the national surveillance was heterogeneous. Among six countries not using typing for TB surveillance, more than half planned its implementation soon. Overall, most countries perceived an added public health value of molecular typing for TB control. Concerning international cluster investigations, countries had little experience and did not have standard protocols to exchange typing data. Conclusion Our study shows a wide use of molecular and genomic typing data for TB surveillance in EU/EEA countries and reveals that transition to WGS-based typing is ongoing or is considered in most countries. However, our results also show a high heterogeneity in the use and integration of typing data for TB surveillance. Standardization of typing data use for TB surveillance is needed and formal procedures should be developed to facilitate international collaboration. © 2019 Andrés et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Andrés, Marta
Germany, Berlin
Robert Koch Institute
van der Werf, Marieke Johanna
Sweden, Solna
European Centre for Disease Prevention and Control
Ködmön, Csaba
Sweden, Solna
European Centre for Disease Prevention and Control
Albrecht, Stefan
Germany, Berlin
Robert Koch Institute
Haas, Walter H.
Germany, Berlin
Robert Koch Institute
Fiebig, Lena
Germany, Berlin
Robert Koch Institute
Indra, Alexander
Unknown Affiliation
Wanlin, Maryse
Unknown Affiliation
Bachiyska, Elizabeta V.
Unknown Affiliation
Zemanová, Ilona
Unknown Affiliation
Lillebæk, Troels
Unknown Affiliation
Viiklepp, Piret
Unknown Affiliation
Haanperä, Marjo S.
Unknown Affiliation
Sougakoff, Wladimir
Unknown Affiliation
Bakos, Ágnes
Unknown Affiliation
Jackson, Sarah
Unknown Affiliation
Cirillo, D. M.
Unknown Affiliation
Vasiliauskienė, Edita
Unknown Affiliation
de Vries, Gerard
Unknown Affiliation
Augustynowicz-Kopeć, Ewa M.
Unknown Affiliation
Duarte, R. A.B.
Unknown Affiliation
Homorodean, Daniela
Unknown Affiliation
Svetina, Petra
Unknown Affiliation
Groenheit, Ramona
Unknown Affiliation
Statistics
Citations: 4
Authors: 24
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0210080
ISSN:
19326203
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative