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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of HIV infection status and Anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants
Journal of Infectious Diseases, Volume 202, No. 3, Year 2010
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Description
Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4+ cell percentages ≥25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART+ group). Immune responses were also evaluated in HIV-noninfected infants born to HIV-seronegative (M+/I+) or HIV-positive mothers (M+/I+). Antibody concentrations were similar between HIV+/ART+ and HIV+/ART+ infants. However, antibody concentrations were lowerin M+/I+ infants than in M+/I+ infants. Nevertheless, M+/I+ infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART+ infants. © 2010 by the Infectious Diseases Society of America.
Authors & Co-Authors
Madhi, Shabir A.
South Africa, Polokwane
Faculty of Health Sciences
Adrian, Peter V.
South Africa, Polokwane
Faculty of Health Sciences
Cotton, Mark Fredric
South Africa, Stellenbosch
Stellenbosch University
McIntyre, James Alasdair
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
Anova Health Institute
Jean-Philippe, Patrick
United States, Bethesda
Henry Jackson Foundation
Meadows, Shawn
United States, Wilmington
Pharmaceutical Product Development, Llc.
Nachman, Sharon A.
United States, Stony Brook
Stony Brook University
Käyhty, Helena M.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Klugman, K. P.
South Africa, Polokwane
Faculty of Health Sciences
United States, Atlanta
Emory University
Violari, Avy
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 10
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1086/653704
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Approach
Qualitative
Quantitative