Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chaxamycins A - D, bioactive ansamycins from a hyper-arid desert streptomyces sp.
Journal of Natural Products, Volume 74, No. 6, Year 2011
Notification
URL copied to clipboard!
Description
Streptomyces sp. strain C34, isolated from soil collected in the Chilean hyper-arid Atacama Desert, was cultured on different media, resulting in the isolation and identification of four new ansamycin-type polyketides. The organism was selected for chemical investigation on the basis of a genome-mining PCR-based experiment targeting the gene encoding rifamycin-specific 3-amino-5-hydroxybenzoic acid synthetase (AHBA). The isolated compounds were structurally characterized using NMR and MS techniques and named chaxamycins A - D (1 - 4). Compounds 1 - 4 were tested for their antibacterial activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 and for their ability to inhibit the intrinsic ATPase activity of the heat shock protein 90 (Hsp90). Chaxamycin D (4), which showed a selective antibacterial activity against S. aureus ATCC 25923, was tested further against a panel of MRSA clinical isolates. In a virtual screening experiment, chaxamycins A - D (1 - 4) have also been docked into the ATP-binding pocket in the N-terminal domain of the Hsp90, and the observed interactions are discussed. © 2011 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Rateb, Mostafa Ezzat M.
United Kingdom, Aberdeen
University of Aberdeen
Egypt, Beni Suef
Faculty of Pharmacy
Houssen, Wael E.
United Kingdom, Aberdeen
University of Aberdeen
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Arnold, Markus
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Abdelrahman, Mostafa H.
United Kingdom, Aberdeen
University of Aberdeen
Deng, Hai
United Kingdom, Aberdeen
University of Aberdeen
Okoro, Chinyere K.
United Kingdom, Newcastle
Newcastle University
Asenjo, Juan A.
Chile, Santiago
Universidad de Chile
Andrews, Barbara A.
Chile, Santiago
Universidad de Chile
Ferguson, Gail
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Bull, Alan T.
United Kingdom, Canterbury
University of Kent
Goodfellow, Michael
United Kingdom, Newcastle
Newcastle University
Ebel, Rainer
United Kingdom, Aberdeen
University of Aberdeen
Jaspars, Marcel
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 113
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1021/np200320u
ISSN:
01633864
e-ISSN:
15206025
Research Areas
Environmental
Genetics And Genomics
Study Approach
Quantitative