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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Less invasive surfactant administration is associated with improved pulmonary outcomes in spontaneously breathing preterm infants
Acta Paediatrica, International Journal of Paediatrics, Volume 104, No. 3, Year 2015
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Description
Aim Providing less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA-treated infants and controls. Methods Infants receiving LISA, who were born before 32 gestational weeks and enrolled in the German Neonatal Network, were matched to control infants by gestational age, umbilical cord pH, Apgar-score at 5 min, small for gestational age status, antenatal treatment with steroids, gender and highest supplemental oxygen during the first 12 h of life. Outcome data were compared with chi-square and Mann-Whitney U-tests and adjusted for multiple comparisons. Results Between 2009 and 2012, 1103 infants were treated with LISA at 37 centres. LISA infants had lower rates of mechanical ventilation (41% versus 62%, p < 0.001), postnatal dexamethasone treatment (2.5% versus 7%, p < 0.001), BPD (12% versus 18%, p = 0.001) and BPD or death (14% versus 21%, p < 0.001) than the controls. Conclusion Surfactant treatment of spontaneously breathing infants was associated with lower rates of mechanical ventilation and BPD. Additional large-scale randomised controlled trials are needed to assess the possible long-term benefits of LISA. ©2014 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Göpel, Wolfgang
Germany, Lubeck
Universität zu Lübeck
Härtel, Christoph
Germany, Lubeck
Universität zu Lübeck
Avenarius, Stefan
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Teig, Norbert
Germany, Bochum
Ruhr-universitat Bochum
Groneck, Peter A.
Unknown Affiliation
Roll, Claudia
Unknown Affiliation
Vochem, Matthias
Germany, Stuttgart
Klinikum Stuttgart Olgahospital
Weller, Ursula
Unknown Affiliation
Wieg, Christian
Germany, Aschaffenburg
Klinikum Aschaffenburg
Wintgens, Jürgen
Unknown Affiliation
Preuss, Michael H.
Germany, Lubeck
Universität zu Lübeck
Ziegler, Andreas E.
Germany, Lubeck
Universität zu Lübeck
Herting, Egbert
Germany, Lubeck
Universität zu Lübeck
Statistics
Citations: 114
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1111/apa.12883
ISSN:
08035253
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative