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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Allelic Discrimination of Vitamin D Receptor Polymorphisms and Risk of Type 2 Diabetes Mellitus: A Case-Controlled Study
Healthcare (Switzerland), Volume 11, No. 4, Article 485, Year 2023
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Description
(1) Background: Type 2 diabetes mellitus (T2DM) is one of the rapidly growing healthcare problems, and several vitamin D receptor (VDR) polymorphisms seem to modulate the risk of T2DM. Our research was designed to investigate the allelic discrimination of VDR polymorphisms and T2DM occurrence risk. (2) Methods: This case-control research included 156 patients with T2DM and 145 healthy control subjects. Most of the study population were males 56.6% vs. 62.8% in the case and control groups, respectively. Genotyping for VDR single nucleotide polymorphisms (SNPs), rs228570 (Fok1), rs7975232 (Apa1), and rs1544410 (Bsm1) was compared between both groups. (3) Results: There was a negative link between vitamin D levels and insulin sensitivity. A significant difference was noted in the allelic discrimination of VDR polymorphism rs228570 and rs1544410 between the study groups (p < 0.001). No difference was observed in the allelic discrimination of VDR polymorphism rs7975232 between the groups (p = 0.063). Moreover, T2DM patients had significantly higher levels of fasting blood sugar (FBS), glycated hemoglobin HbA1c, 2-h post-prandial blood sugar (PP), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), total cholesterol, and triglycerides (p < 0.001), while High-Density Lipoprotein (HDL) Cholesterol (HDL-C) was significantly decreased (p = 0.006). (4) Conclusions: VDR polymorphisms had a positive association with T2DM risk among the Egyptian population. Further large-scale research using deep sequencing of samples is strongly urged to investigate different vitamin D gene variants and interactions, as well as the influence of vitamin D on T2DM. © 2023 by the authors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9956945/bin/healthcare-11-00485-s001.zip
Authors & Co-Authors
Mohammed, Amal Ahmed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Matty, Dina M.Abo
Egypt, Ismailia
Suez Canal University
Abdel-Azeem, Rola
Egypt, Ismailia
Suez Canal University
Raafat, Khaled Mohamed
Egypt, Cairo
Ain Shams University
Hussein, Mona Abd Elmotaleb A.
Egypt, Cairo
National Institute of Diabetes and Endocrinology
El-Ansary, Amira R.
Egypt, 6th October
Misr University for Science and Technology
Hafez, Wael
Egypt, Giza
National Research Centre
Hassan, Hatem Ahmed
Egypt, Minya
Minia University
Nassar, Nourelhuda Ahmed
Egypt, Cairo
El-sahel Teaching Hospital
Selim, Nora Mahmoud
Egypt, Giza
Cairo University
Ghaith, Doaa Mohammad
Egypt, Giza
Cairo University
El-Kholy, Amal A.
Egypt, Cairo
Ain Shams University
Abd El Salam, Soha M.
Egypt, Suez
Suez University
Al Anouti, Fatme
United Arab Emirates, Dubai
Zayed University
Wahba, Alaa Samir M.
Egypt, Ismailia
Suez Canal University
Statistics
Citations: 1
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.3390/healthcare11040485
ISSN:
22279032
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study