Anticholinergic syndrome following ocular instillation of atropine eye drops: A case report

Atropine-based eye drops are commonly used mainly in the treatment of chronic open-angle glaucoma and uveitis. Topical atropine-based products are not devoid of systemic effects, and possible atropine intoxication should be considered when faced with an unexplained atropine syndrome. We report the case of an 80-year-old man who consults in the emergency department for micturition difficulties, dry mouth and tears as well as visual disturbances evolving for a week. Toxicological analyzes by gas chromatography and LC-MS/MS confirmed the diagnosis of systemic atropine intoxication following the instillation of eye drops for the treatment of glaucoma.