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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Self-assembly of a nanoscale DNA box with a controllable lid
Nature, Volume 459, No. 7243, Year 2009
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Description
The unique structural motifs and self-recognition properties of DNA can be exploited to generate self-assembling DNA nanostructures of specific shapes using a bottom-up approach. Several assembly strategies have been developed for building complex three-dimensional (3D) DNA nanostructures. Recently, the DNA origami method was used to build two-dimensional addressable DNA structures of arbitrary shape that can be used as platforms to arrange nanomaterials with high precision and specificity. A long-term goal of this field has been to construct fully addressable 3D DNA nanostructures. Here we extend the DNA origami method into three dimensions by creating an addressable DNA box 42 × 36 × 36 nm 3 in size that can be opened in the presence of externally supplied DNA keys. We thoroughly characterize the structure of this DNA box using cryogenic transmission electron microscopy, small-angle X-ray scattering and atomic force microscopy, and use fluorescence resonance energy transfer to optically monitor the opening of the lid. Controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications, for example as a logic sensor for multiple-sequence signals or for the controlled release of nanocargos. © 2009 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Dong, Mingdong
Denmark, Copenhagen
Danmarks Grundforskningsfond
Denmark, Aarhus
Aarhus Universitet
United States, Cambridge
Harvard University
Mamdouh, Wael
Denmark, Copenhagen
Danmarks Grundforskningsfond
Denmark, Aarhus
Aarhus Universitet
Oliveira, Cristiano Luis Pinto
Denmark, Aarhus
Aarhus Universitet
Pedersen, Jan Skov
Denmark, Aarhus
Aarhus Universitet
Besenbacher, Flemming
Denmark, Copenhagen
Danmarks Grundforskningsfond
Denmark, Aarhus
Aarhus Universitet
Gothelf, Kurt Vesterager
Denmark, Copenhagen
Danmarks Grundforskningsfond
Denmark, Aarhus
Aarhus Universitet
Statistics
Citations: 1,298
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1038/nature07971
ISSN:
14764687
Research Areas
Genetics And Genomics
Health System And Policy