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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical and epidemiological characteristics of SARS-CoV-2 Infection in Los Angeles County youth during the first year of the pandemic
International Journal of Infectious Diseases, Volume 122, Year 2022
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Description
Objectives: The aim of this study was to characterize SARS-CoV-2 infection patterns in Los Angeles (LA) County youth followed at our institution during the first pandemic year. Design: A prospective cohort of patients aged < 25 years who tested positive for SARS-CoV-2 using reverse-transcriptase polymerase chain reaction (RT-PCR) assays between March 13, 2020, and March 31, 2021, was evaluated at a large LA County health network. Demographics, age distribution, and disease severity were analyzed. Results: There were 28,088 youth aged < 25 years tested for SARS-CoV-2 using RT-PCR, with 1849 positive results identified (7%). Among the positive results, 475 of 11,922 (4%) were identified at the pandemic onset (March-September 2020) (Cohort 1) and 1374 of 16,166 (9%) between October 2020 and March 2021 (Cohort 2), P < 0.001. When disease severity was compared across cohorts, Cohort 2 had a greater proportion of asymptomatic and mild/moderate disease categories than Cohort 1 (98% vs 80%, respectively); conversely, Cohort 1 had a near–10-fold higher proportion of severe disease than Cohort 2 (17% vs 1.8%). Cohort 2 comprised younger patients with a mean age of 13.7 years vs 17.3 years in Cohort 1. Older age was associated with a higher percentage of infection, with 63% of all confirmed cases found in participants aged 19 to 25 years in Cohort 1, compared with 38% of confirmed cases in Cohort 2. Age increase was also associated with greater disease severity by linear regression modeling (P< 0.001). Conclusion: Coronavirus disease 2019 (COVID-19) disease severity in youth decreased over time in LA County during the first pandemic year, likely a reflection of changing demographics, with younger children infected. A higher infection rate in youth did not lead to higher disease severity over time. © 2022 The Author(s)
Authors & Co-Authors
Kerin, Tara K.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Fuller, Trevon L.
United States, Los Angeles
University of California, Los Angeles
Yang, Shangxin
United States, Los Angeles
David Geffen School of Medicine at Ucla
Kamau, Edwin
United States, Los Angeles
David Geffen School of Medicine at Ucla
Garner, Omai B.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Nielsen-Saines, Karin A.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Statistics
Citations: 1
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijid.2022.06.040
ISSN:
12019712
Research Areas
Covid
Maternal And Child Health
Study Design
Cohort Study