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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Oxidative stress, biochemical and histopathological alterations in the liver and kidney of female rats exposed to low doses of deltamethrin (DM): A molecular assessment
Biomedical and Environmental Sciences, Volume 25, No. 6, Year 2012
Notification
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Description
Objective: To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity. Methods: Female Wistar rats were randomly assigned to control (3 groups, 6 rats in each) and treatment groups (3 groups, 6 rats in each). They were subjected to subcutaneous injections of DM (at doses of 0.003, 0.03, and 0.3 mg/kg bw/d) after 30, 45, and 60 d, respectively. Results: Significant alterations were recorded in liver parenchyma induced by hepatic vacuolization, fragmented chromatin in nuclei, dilatation of sinusoids and congestions. Lesions within proximal and distal tubules were observed in the kidneys. Tissue congestions and severe alterations within glomeruli were visible. DM as a pyrethroid insecticide induced significant increase (P≤0.05) of plasma MDA concentrations after 45 d. A significant increase (P≤0.05) in plasma ALT (after 45 and 60 d) and AST (after 60 d) concentrations was recorded as compared to controls. During the whole experimental period the toxic agent provoked significant DNA damages (P≤0.05), especially in the dominance of classes 3 and 4 of obtained comet. Conclusion: DM even at a very low dose displays harmful effects by disrupting hepatic and renal function and causing DNA damages in puberscent female rats. Low doses of DM are hepatotoxic and nephrotoxic. © 2012 The Editorial Board of Biomedical and Environmental Sciences.
Authors & Co-Authors
Chargui, Issam
Tunisia, Monastir
Faculté de Médecine de Monastir
Grissa, Intissar
Tunisia, Monastir
Faculté de Médecine de Monastir
Bensassi, Fatma
Tunisia, Monastir
Faculty of Dentistry
Tunisia, Tunis
University of Carthage, Institut National de la Recherche Agronomique de Tunisie
Hrira, Mohamed Yahia
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Haouem, Samir
Tunisia, Monastir
Faculté de Médecine de Monastir
Haouas, Zohra
Tunisia, Monastir
Faculté de Médecine de Monastir
Bencheikh, Hassen
Tunisia, Monastir
Faculté de Médecine de Monastir
Statistics
Citations: 88
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.3967/0895-3988.2012.06.009
ISSN:
08953988
Research Areas
Environmental
Genetics And Genomics
Participants Gender
Female