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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique
International Journal of Oral and Maxillofacial Surgery, Volume 39, No. 2, Year 2010
Notification
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Description
The use of prophylactic antibiotics to reduce postoperative complications in third molar surgery remains controversial. The study was a prospective, randomized, double blind, placebo-controlled clinical trial. 100 patients were randomly assigned to two groups. Each patient acted as their own control using the split-mouth technique. Two unilateral impacted third molars were removed under antibiotic cover and the other two were removed without antibiotic cover. The first group received antibiotics on the first surgical visit. On the second surgical visit (after 3 weeks), placebo capsules were given or vice versa. The second group received antibiotics with continued therapy for 2 days on the first surgical visit and on the second surgical visit (after 3 weeks) placebo capsules were given or vice versa. Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery. Of 380 impactions, 6 sockets (2%) became infected. There was no statistically significant difference in the infection rate, pain, swelling, trismus, and temperature between the two groups (p > 0.05). Results of the study showed that prophylactic antibiotics did not have a statistically significant effect on postoperative infections in third molar surgery and should not be routinely administered when third molars are removed in non-immunocompromised patients. © 2009 International Association of Oral and Maxillofacial Surgeons.
Authors & Co-Authors
Siddiqi, Allauddin
New Zealand, Dunedin
Faculty of Dentistry
Morkel, Jean A.
South Africa, Bellville
University of the Western Cape
Zafar, Sobia
New Zealand, Dunedin
Faculty of Dentistry
Statistics
Citations: 114
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijom.2009.12.014
ISSN:
09015027
Research Areas
Disability
Health System And Policy
Study Design
Cohort Study