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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of Kaposi's sarcoma by combination of actinomycin‐D, vincristine and imidazole carboxamide (NSC‐45388): Results of a randomized clinical trial
International Journal of Cancer, Volume 14, No. 5, Year 1974
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Description
Previous trials at our Institute revealed the effectiveness of actinomycin‐D and vincristine in the treatment of Kaposi's Sarcoma. We herein report the results of a further randomized trial designed to test the efficacy of the three‐drug combination consisting of actinomycin‐D, vincristine and imidazole carboxamide and to compare the results with those obtained by combining actinomycin‐D and vincristine only for all forms of Kaposi's Sarcoma. Of the 40 patients treated with two drugs, 22 (55%) achieved complete tumour regression, 13 (32.5%) had partial response and 5 (12.5%) did not respond. On the other hand, 30 out of 32(94%) of those receiving three drugs had complete tumour regression, one had partial and one had no response. There is a significantly higher complete response rate (p<0.002) in the group receiving three drugs than in that receiving two drugs. The side effects encountered were comparable. Copyright © 1974 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Olweny, Charles L.M.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Toya, Tom
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Katongole-Mbidde, Edward
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Lwanga, Stephen K.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Owor, Raphael
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Kyalwazi, Sebastian K.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Vogel, Charles L.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Atlanta
Emory University School of Medicine
Statistics
Citations: 44
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1002/ijc.2910140512
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Study Design
Randomised Control Trial