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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum β-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa
International Journal of Antimicrobial Agents, Volume 31, No. 6, Year 2008
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Description
Several different Guiana extended-spectrum (GES) enzymes have been described occurring in Enterobacteriaceae and Pseudomonas aeruginosa worldwide. Polymerase chain reaction and gene sequencing analysis confirmed blaGES genes identified in three P. aeruginosa clinical isolates from South Africa as blaGES-5 and blaGES-5-like, respectively. Compared with GES-1, the GES-5-like protein exhibited an A21E amino acid change, a novel mutation not previously described in this family. Integron structures identified upstream from the blaGES-5 and blaGES-5-like genes were found to be identical to blaGES-2-carrying integrons described previously from the same geographical region. These findings confirm the establishment and persistence of integron-associated GES-type extended-spectrum β-lactamases (ESBLs) in the South African nosocomial environment. This study describes the first isolation of class 1 integron-associated blaGES-5 and the emergence of a novel GES-5-like ESBL in South Africa. © 2008.
Authors & Co-Authors
Labuschagne, Christiaan De J.
South Africa, Pretoria
Inqaba Biotechnical Industries
South Africa, Pretoria
Faculty of Health Sciences
Weldhagen, Gerhard F.
South Africa, Highveld Park
Ampath Trust
Ehlers, Marthie Magdaleen
South Africa, Pretoria
Faculty of Health Sciences
Dove, Michael G.
South Africa, Pretoria
Faculty of Health Sciences
Statistics
Citations: 38
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijantimicag.2008.01.020
ISSN:
09248579
Research Areas
Cancer
Genetics And Genomics
Study Locations
South Africa