Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection
AIDS, Volume 16, No. 11, Year 2002
Notification
URL copied to clipboard!
Description
Objectives: To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation. Methods: Plasma samples were obtained from HIV-1-infected individuals (n = 10) at diagnosis of acute malaria, 4 weeks after parasite clearance and from HIV-infected aparasitemic controls (n = 10). Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using enzyme-linked immunosorbent assays. Results: Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. Conclusions: Acute P. falciparum malaria coinfection impacts virus-host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation. © 2002 Lippincott Williams & Wilkins.
Authors & Co-Authors
Pisell, Tracy L.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Jere, Charles S.
Malawi, Zomba
University of Malawi
Ballard, Sarah B.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Butera, Salvatore T.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Lawn, Stephen D.
United States, Atlanta
Centers for Disease Control and Prevention
United Kingdom, London
Hospital for Tropical Diseases
Statistics
Citations: 55
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1097/00002030-200207260-00007
Research Areas
Infectious Diseases