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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
T cell-derived TNF down-regulates acute airway response to endotoxin
European Journal of Immunology, Volume 37, No. 3, Year 2007
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Description
Acute and chronic airway inflammations caused by environmental agents including endotoxin represent an increasing health problem. Local TNF production may contribute to lung dysfunction and inflammation, although pulmonary neutrophil recruitment occurs in the absence of TNF. First, we demonstrate that membrane-bound TNF is sufficient to mediate the inflammatory responses to lipopolysaccharide (LPS). Secondly, using cell type-specific TNF-deficient mice we show that TNF derived from either macrophage/neutrophil (M/N) or T lymphocytes have differential effects on LPS-induced respiratory dysfunction (enhanced respiratory pause, Penh) and pulmonary neutrophil recruitment. While Penh, vascular leak, neutrophil recruitment, TNF, and thymus- and activation-regulated chemokine/CCL17 (TARQ expression in the lung were reduced in M/ N-deficient mice, T cell-specific TNF-deficient mice displayed augmented Penh, vascular leak, neutrophil influx, increased CD11c+ cells and expression of TNF, TARC and murine CXC chemokines KC/CXCL1 in the lung. In conclusion, inactivation of TNF in either M/N or T cells has differential effects on LPS-induced lung disease, suggesting that selective deletion of TNF in T cells may aggravate airway pathology. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Togbé, Dieudonnée
France, Orleans
Université D'orléans
Grivennikov, Sergei I.
Russian Federation, Moscow
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Noulin, Nicolas
France, Orleans
Key-obs S.a.
Couillin, Isabelle
France, Orleans
Key-obs S.a.
Maillet, Isabelle
France, Orleans
Université D'orléans
Jacobs, Muazzam
South Africa, Cape Town
University of Cape Town
Mare, Marielle
France, Orleans
Université D'orléans
Fick, Lizette C.E.
South Africa, Cape Town
University of Cape Town
Nedospasov, Sergei A.
Russian Federation, Moscow
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Quesniaux, Valérie F.J.
France, Orleans
Université D'orléans
Schnyder, Bruno
France, Orleans
Université D'orléans
Switzerland
Biomedical Research Foundation
Schnyder-Candrian, Silvia
France, Orleans
Université D'orléans
Statistics
Citations: 12
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1002/eji.200636371