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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Enhancement of fungicidal and insecticidal activity by reductive alkylation of chitosan
Pest Management Science, Volume 62, No. 9, Year 2006
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Description
A series of N-alkyl chitosan (NAC) derivatives were synthesized using a reductive alkylation reaction to examine their fungicidal and insecticidal activity. The chemical structures were characterized by IR and 1H NMR spectroscopy, and the degree of substitution (DS) ranged from 0.02 to 0.37. Their fungicidal activity was evaluated against the grey mould Botrytis cinerea Pers ex Fr (Leotiales: Sclerotiniaceae) and the rice leaf blast pathogen Pyricularia grisea Sacc [Teleomorph: Magnaporthe grisea (Hebert) Barr] by a radial growth bioassay. It was of interest that most of the NAC derivatives were more active against both fungi than chitosan itself. The most active derivative was N-(2,2-diphenylethyl)chitosan with EC50 values of 0.031 and 0.23 gL-1 against B. cinerea and P. grisea respectively. In addition, some derivatives, at higher concentrations up to 1.0 g L-1, inhibited the mycelial growth and spore formation of P. grisea. Bioassays against larvae of the cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) with the NAC derivatives at a rate of 5.0 g kg-1 in artificial diet demonstrated that N-(3-phenylbutyl)chitosan was the most active compound. In addition, N-propylchitosan, N-undecanylchitosan and N-(3-phenylpropyl)chitosan derivatives strongly inhibited larval weight gain in S. littoralis, with respective reductions of 76, 66 and 65% after 4 days of feeding on treated diet. © 2006 Society of Chemical Industry.
Authors & Co-Authors
Rabea, Entsar I.
Belgium, Ghent
Universiteit Gent
Badawy, Mohamed E.I.
Belgium, Ghent
Universiteit Gent
Rogge, Tina M.
Belgium, Ghent
Universiteit Gent
Stevens, Christian V.
Belgium, Ghent
Universiteit Gent
Steurbaut, Walter
Belgium, Ghent
Universiteit Gent
Höfte, Monica M.
Belgium, Ghent
Universiteit Gent
Smagghe, Guy J.
Belgium, Ghent
Universiteit Gent
Statistics
Citations: 57
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.1002/ps.1263
ISSN:
15264998