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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Nature Neuroscience, Volume 25, No. 4, Year 2022
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Description
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging. © 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Brouwer, Rachel M.
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Amsterdam
Amsterdam Neuroscience
Klein, Marieke
Netherlands, Utrecht
Universiteit Utrecht
United States, La Jolla
University of California, San Diego
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Nijmegen
Radboud Universiteit
Grasby, Katrina L.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Schnack, Hugo G.
Netherlands, Utrecht
Universiteit Utrecht
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Teeuw, Jalmar
Netherlands, Utrecht
Universiteit Utrecht
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
Sprooten, Emma
Netherlands, Nijmegen
Radboud University Medical Center
Franz, Carol E.
United States, La Jolla
University of California, San Diego
Gogtay, Nitin
United States, Washington, D.c.
American Psychiatric Association
Kremen, William S.
United States, La Jolla
University of California, San Diego
United States
Va Medical Center
Panizzon, Matthew S.
United States, La Jolla
University of California, San Diego
Olde Loohuis, Loes M.
United States, Los Angeles
University of California, Los Angeles
Whelan, Christopher D.
United States, Cambridge
Biogen Inc.
Aghajani, Moji
Netherlands, Amsterdam
Amsterdam Neuroscience
Netherlands, Leiden
Universiteit Leiden
Alloza, Clara
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Alnæs, Dag
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Artiges, Éric
France, Gif-sur-yvette
École Normale Supérieure Paris-saclay
Ayesa-Arriola, Rosa
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Barker, Gareth J.
United Kingdom, London
King's College London
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
Blok, Elisabet
Netherlands, Rotterdam
Erasmus Mc
Bøen, Erlend
Norway, Oslo
Oslo Universitetssykehus
Breukelaar, Isabella A.
Australia, Parramatta
The Westmead Institute for Medical Research
Bright, Joanna K.
United States, Los Angeles
University of Southern California
Buimer, Elizabeth E.L.
Netherlands, Utrecht
Universiteit Utrecht
Bülow, Robin
Germany, Greifswald
Universitätsmedizin Greifswald
Cannon, Dara M.
Ireland, Galway
University of Galway
Ciufolini, Simone
United Kingdom, London
King's College London
Crossley, Nicolas A.
United Kingdom, London
King's College London
Chile, Santiago
Pontificia Universidad Católica de Chile
Damatac, Christienne G.
Netherlands, Nijmegen
Radboud University Medical Center
Dazzan, Paola
United Kingdom, London
King's College London
de Mol, Casper Louk
Netherlands, Rotterdam
Erasmus Mc
de Zwarte, Sonja M.C.
Netherlands, Utrecht
Universiteit Utrecht
Desrivières, Sylvane
United Kingdom, London
King's College London
Díaz-Caneja, M. C.
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Doan, Nhat Trung
Norway, Oslo
Universitetet I Oslo
Dohm, Katharina
Germany, Munster
University of Münster
Fröhner, Juliane Hilde
Germany, Dresden
Technische Universität Dresden
Goltermann, Janik
Germany, Munster
University of Münster
Grigis, Antoine
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Grotegerd, Dominik
Germany, Munster
University of Münster
Han, Laura K.M.
Netherlands, Amsterdam
Amsterdam Neuroscience
Harris, Mathew A.
United Kingdom, Edinburgh
The University of Edinburgh
Hartman, Catharina Annette
Netherlands, Groningen
Rijksuniversiteit Groningen
Heany, Sarah J.
South Africa, Cape Town
University of Cape Town
Heindel, Walter Leonhard
Germany, Munster
Universitätsklinikum Münster
Heslenfeld, Dirk J.
Unknown Affiliation
Hohmann, Sarah
Germany, Heidelberg
Universität Heidelberg
Ittermann, Bernd
Germany, Braunschweig
Physikalisch-technische Bundesanstalt
Jansen, Philip R.
Netherlands, Amsterdam
Amsterdam Neuroscience
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Janssen, Joost
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Jia, Tianye
China, Shanghai
Fudan University
United Kingdom, London
King's College London
Jiang, Jiyang
Australia, Sydney
Unsw Sydney
Jockwitz, Christiane
Germany, Julich
Forschungszentrum Jülich Gmbh
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Karali, Temmuz
Germany, Munich
Klinikum Der Universität München
Keeser, Daniel
Germany, Munich
Klinikum Der Universität München
Koevoets, Martijn G.J.C.
Netherlands, Utrecht
Universiteit Utrecht
Lenroot, Rhoshel K.
Australia, Sydney
Unsw Sydney
United States, Albuquerque
The University of new Mexico
Australia, Sydney
Neuroscience Research Australia
Malchow, Berend
Germany, Gottingen
Universitätsmedizin Göttingen
Mandl, René Christiaan William
Netherlands, Utrecht
Universiteit Utrecht
Medel, Vicente
Chile, Santiago
Pontificia Universidad Católica de Chile
Meinert, Susanne L.
Germany, Munster
University of Münster
Morgan, Catherine A.
New Zealand, Auckland
The University of Auckland
New Zealand, Auckland
Brain Research new Zealand - Rangahau Roro Aotearoa
Mühleisen, Thomas W.
Germany, Julich
Forschungszentrum Jülich Gmbh
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Switzerland, Basel
Universitat Basel
Nabulsi, Leila
Ireland, Galway
University of Galway
Opel, Nils
Germany, Munster
University of Münster
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
de la Foz, Víctor Ortiz García
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Overs, Bronwyn J.
Australia, Sydney
Neuroscience Research Australia
Paillère-Martinot, Marie Laure
France, Gif-sur-yvette
École Normale Supérieure Paris-saclay
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Redlich, Ronny
Germany, Munster
University of Münster
Germany, Halle
Martin-luther-universität Halle-wittenberg
Marques, Tiago R.
United Kingdom, London
King's College London
United Kingdom, London
Medical Research Council
Repple, Jonathan
Germany, Munster
University of Münster
Roberts, Gloria M.P.
Australia, Sydney
Unsw Sydney
Roshchupkin, Gennady Vasilievich
Netherlands, Rotterdam
Erasmus Mc
Setiaman, Nikita
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Rotterdam
Erasmus Mc
Shumskaya, Elena
Netherlands, Nijmegen
Radboud University Medical Center
Stein, Frederike
Germany, Marburg
Philipps-universität Marburg
Sudre, Gustavo P.
United States, Bethesda
National Human Genome Research Institute Nhgri
Takahashi, Shun
Germany, Munich
Klinikum Der Universität München
Japan, Wakayama
Wakayama Medical University
Thalamuthu, Anbupalam
Australia, Sydney
Unsw Sydney
Tordesillas-Gutiérrez, Diana
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Santander
Csic-uc - Instituto de Física de Cantabria Ifca
van der Lugt, Aad J.
Netherlands, Rotterdam
Erasmus Mc
van Haren, Neeltje E.M.
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Rotterdam
Erasmus Mc
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
Wen, Wei
Australia, Sydney
Unsw Sydney
Westeneng, Henk Jan
Netherlands, Utrecht
Universiteit Utrecht
Wittfeld, Katharina
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Germany, Greifswald
Universitätsmedizin Greifswald
Zhu, Alyssa H.
United States, Los Angeles
University of Southern California
Zugman, André
Brazil, Sao Paulo
Universidade Federal de São Paulo
Armstrong, Nicola J.
Australia, Perth
Curtin University
Bonfiglio, Gaia
Netherlands, Amsterdam
Amsterdam Neuroscience
Bralten, Janita B.
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Nijmegen
Radboud Universiteit
Dalvie, Shareefa
South Africa, Cape Town
University of Cape Town
Davies, Gail
United Kingdom, Edinburgh
The University of Edinburgh
Di Forti, Marta
United Kingdom, London
King's College London
Ding, Linda
United States, Los Angeles
University of Southern California
Donohoe, Gary J.
Ireland, Galway
University of Galway
Forstner, Andreas J.
Germany, Julich
Forschungszentrum Jülich Gmbh
Germany, Marburg
Philipps-universität Marburg
Germany, Bonn
Universität Bonn
González-Peñas, Javier
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Homuth, Georg
Germany, Greifswald
Universitätsmedizin Greifswald
Hottenga, Jouke Jan
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Knol, Maria J.
Netherlands, Rotterdam
Erasmus Mc
Kwok, John B.J.
Australia, Sydney
The University of Sydney
Australia, Sydney
Unsw Sydney
Le Hellard, Stéphanie
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Mather, Karen A.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Milaneschi, Yuri
Netherlands, Amsterdam
Amsterdam Neuroscience
Morris, Derek W.
Ireland, Galway
University of Galway
Nöthen, Markus Maria
Germany, Bonn
Universität Bonn
Rietschel, Marcella D.C.
Germany, Heidelberg
Universität Heidelberg
Leite Santoro, Marcos Leite
Brazil, Sao Paulo
Universidade Federal de São Paulo
Steen, Vidar Martin
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Stein, Jason L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Streit, Fabian E.
Germany, Heidelberg
Universität Heidelberg
Teumer, Alexander
Germany, Greifswald
Universitätsmedizin Greifswald
van der Meer, Dennis
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Netherlands, Maastricht
Universiteit Maastricht
van Eijk, Kristel R.
Netherlands, Utrecht
Universiteit Utrecht
Váquez-Bourgon, Javier
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Witt, Stephanie H.
Germany, Heidelberg
Universität Heidelberg
Brühl, Rüdiger
Germany, Braunschweig
Physikalisch-technische Bundesanstalt
Papadopoulos-Orfanos, Dimitri
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Paus, Tomáš
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
Canada, Toronto
University of Toronto
Millenet, Sabina K.
Germany, Heidelberg
Universität Heidelberg
Adams, Hieab H.H.
Netherlands, Rotterdam
Erasmus Mc
Chile, Santiago
Universidad Adolfo Ibáñez
Agartz, Ingrid A.
Norway, Oslo
Universitetet I Oslo
Sweden, Stockholm
Karolinska Institutet
Norway, Oslo
Diakonhjemmet Sykehus
Ames, David J.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
National Ageing Research Institute
Amunts, Katrin
Germany, Julich
Forschungszentrum Jülich Gmbh
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Arango, Celso
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Banaschewski, Tobias J.
Germany, Heidelberg
Universität Heidelberg
Baune, Bernhard T.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Germany, Munster
University of Münster
Belangero, Síntia Iole Nogueira Iole Nogueira
Brazil, Sao Paulo
Universidade Federal de São Paulo
Bokde, Arun L.W.
Ireland, Dublin
Trinity College Dublin
Boomsma, Dorret I.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Bressan, Rodrigo Affonsecca
Brazil, Sao Paulo
Universidade Federal de São Paulo
Brodaty, Henry
Australia, Sydney
Unsw Sydney
Buitelaar, Jan K.
Netherlands, Nijmegen
Radboud University Medical Center
Cahn, Wiepke
Netherlands, Utrecht
Universiteit Utrecht
Caspers, Svenja
Germany, Julich
Forschungszentrum Jülich Gmbh
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Cichon, Sven
Germany, Julich
Forschungszentrum Jülich Gmbh
Switzerland, Basel
Universitat Basel
Crespo-Facorro, Benedicto
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Sevilla
Facultad de Medicina, Universidad de Sevilla
Cox, Simon R.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Dannlowski, Udo
Germany, Munster
University of Münster
Elvsåshagen, Torbjorn
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Espeseth, Thomas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Bjorknes University College
Falkai, Peter G.
Germany, Munich
Klinikum Der Universität München
Fisher, Simon E.
Netherlands, Nijmegen
Radboud Universiteit
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Flor, Herta
Germany, Heidelberg
Universität Heidelberg
Fullerton, Janice M.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Garavan, Hugh P.
United States, Burlington
The University of Vermont
Gowland, Penny Anne
United Kingdom, Nottingham
University of Nottingham
Grabe, Hans Jörgen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Germany, Greifswald
Universitätsmedizin Greifswald
Hahn, Tim
Germany, Munster
University of Münster
Heinz, Andreas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Hillegers, Manon H.J.
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Rotterdam
Erasmus Mc
Hoare, Jacqueline
South Africa, Cape Town
University of Cape Town
United Kingdom, Plymouth
Peninsula Medical School, Universities of Exeter and Plymouth
Hoekstra, Pieter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Jackowski, Andrea Parolin
Brazil, Sao Paulo
Universidade Federal de São Paulo
Jansen, Andreas
Germany, Marburg
Philipps-universität Marburg
Jönsson, Erik Gunnar
Norway, Oslo
Universitetet I Oslo
Sweden, Stockholm
Karolinska Institutet
Kahn, René Sylvain
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Kircher, Tilo T.J.
Germany, Marburg
Philipps-universität Marburg
Korgaonkar, Mayuresh S.
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
The University of Sydney
Krug, Axel
Germany, Marburg
Philipps-universität Marburg
Germany, Bonn
Universität Bonn
Lemaître, Hervé S.
France, Bordeaux
Institut Des Maladies Neurodégénératives
Malt, Ulrik Fredrik
Norway, Oslo
Universitetet I Oslo
Martinot, Jean Luc
France, Gif-sur-yvette
École Normale Supérieure Paris-saclay
McDonald, Colm D.
Ireland, Galway
University of Galway
Mitchell, Philip B.
Australia, Sydney
Unsw Sydney
Muetzel, Ryan L.
Netherlands, Rotterdam
Erasmus Mc
Murray, Robin M.
United Kingdom, London
King's College London
Nees, Frauke
Germany, Heidelberg
Universität Heidelberg
Germany, Kiel
Christian-albrechts-universität zu Kiel
Nenadić, Igor
Germany, Marburg
Philipps-universität Marburg
Oosterlaan, Jaap
Netherlands, Amsterdam
Amsterdam Reproduction and Development
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Ophoff, Roel A.
United States, Los Angeles
University of California, Los Angeles
Netherlands, Rotterdam
Erasmus Universiteit Rotterdam
Pan, Pedro Mario
Brazil, Sao Paulo
Universidade Federal de São Paulo
Penninx, Brenda W. J. H.
Netherlands, Amsterdam
Amsterdam Neuroscience
Schumann, Gunter
Germany, Gottingen
Universitätsmedizin Göttingen
Sachdev, Perminder S.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Prince of Wales Hospital
Salum, Giovanni Abrahão
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Brazil, Porto Alegre
Hospital de Clinicas de Porto Alegre
Schofield, Peter R.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Schumann, Gunter
China, Shanghai
Fudan University
Germany, Berlin
Charité – Universitätsmedizin Berlin
Sim, Kang
Singapore, Singapore City
Singapore Institute of Mental Health
Singapore, Singapore City
National University of Singapore
Smolka, Michael N.
Germany, Dresden
Technische Universität Dresden
Stein, Dan J.
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Trollor, Julian N.
Australia, Sydney
Unsw Sydney
van den Berg, Leonard H.
Netherlands, Utrecht
Universiteit Utrecht
Veldink, Jan Herman
Netherlands, Utrecht
Universiteit Utrecht
Walter, Henrik
Germany, Berlin
Freie Universität Berlin
Westlye, Lars T.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Whelan, Robert
Ireland, Dublin
Trinity College Dublin
White, T. J.
Netherlands, Rotterdam
Erasmus Mc
Wright, Margaret J.
Australia, Brisbane
The University of Queensland
Medland, Sarah E.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Franke, Barbara
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Nijmegen
Radboud Universiteit
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Hulshoff Pol, Hilleke E.
Netherlands, Utrecht
Universiteit Utrecht
Statistics
Citations: 71
Authors: 198
Affiliations: 95
Identifiers
Doi:
10.1038/s41593-022-01042-4
ISSN:
10976256
Research Areas
Genetics And Genomics
Mental Health
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Systematic review