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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effect of Malnutrition on Rotavirus Infection in Suckling Mice: Kinetics of Early Infection
Proceedings of the Society for Experimental Biology and Medicine, Volume 178, No. 1, Year 1985
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Description
The effects of malnutrition on the viral replication pattern and severity of clinical disease were examined in suckling mice infected with mouse rotavirus (MRV). The infection in malnourished animals was characterized by a significant decrease in the minimal infectious dose and in the incubation period of the onset of diarrhea, when compared to well-nourished controls. Viral replication in the dispersed enterocytes was observed 6-12 hr earlier, fecal viral shedding peaked significantly earlier, and the clinical disease appeared to be more severe in the malnourished animals than in the controls. These observations provide strong evidence for malnutrition-induced alterations in the pathogenesis of rotaviral infection in vivo. © 1985, SAGE Publications. All rights reserved.
Authors & Co-Authors
Offor, Elsie C.
Nigeria, Benin
University of Benin
Riepenhoff-Talty, Marie
Nigeria, Benin
University of Benin
Ogra, Pearay L.
United States, Buffalo
Women and Children's Hospital of Buffalo
Statistics
Citations: 19
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.3181/00379727-178-41987
ISSN:
00379727
e-ISSN:
15353699
Research Areas
Food Security