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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Combination antiretroviral therapy and duration of pregnancy
AIDS, Volume 14, No. 18, Year 2000
Notification
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Description
Objective: To assess the association between type and timing of initiation of antiretroviral therapy in pregnancy and duration of pregnancy. Design: Prospective study. Methods: Data on 3920 mother child pairs were examined (3015 mother-child pairs from the European Collaborative Study and 905 from the Swiss Mother + Child HIV Cohort Study). Factors examined included gestational age, antiretroviral therapy during pregnancy, maternal CD4 count, viral load, illicit drug use (IDU) and mode of delivery. Deliveries at less than 37 weeks were defined as premature. Results: The prematurity rate was 17% and median gestational age 39 weeks. Twenty-three per cent (896 of 3920) of women received antiretroviral therapy during pregnancy: 64% (573 of 896) zidovudine monotherapy, 24% (215) combination therapy without protease inhibitors (PI) and 12% (108) combination therapy with PI. In multivariate analysis, adjusted for maternal CD4 count and IDU, odds ratio (OR) of prematurity was 2.60 195% confidence interval (CI), 1.43-4.751 and 1.82 (95% CI, 1.13-2.92) for infants exposed to combination therapy with and without a Pl, respectively, compared to no treatment. Exposure to monotherapy was not associated with prematurity, but severe immunosuppression and IDU in pregnancy were. Women on combination therapy from before pregnancy were twice as likely to deliver prematurely as those starting therapy in the third trimester (OR, 2.17 95% CI, 1.03-4.58). Conclusions: Pregnancy issues should be discussed when making decisions about initiation of combination antiretroviral therapy for HIV-infected women. Elective caesarean section to reduce vertical transmission at 36 weeks rather than 38 weeks may be advisable in women on combination therapy with PI. © 2000 Lippincott Williams & Wilkins.
Authors & Co-Authors
Newell, Marie Louise
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Battegay, Manuel
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Bernasconi, Enos
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Biedermann, Kurt J.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Erb, Peter
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Flepp, Markus J.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Francioli, Patrick B.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Furrer, Hansjakob
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Hirschel, Bernard J.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Hösli, Irene Mathilde
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Kind, Christian H.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Perrin, Luc Henri
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Rickenbach, Martin
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Rudin, Christoph
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Schüpbach, Jörg Rg
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Telenti, Amalio
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Vernazza, Pietro Luigi
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Giaquinto, Carlo
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Ruga, Ezia Maria
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
De Rossi, Anita
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Seel, Karen
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Schäfer, Axel P.A.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Mok, Jacqueline Y.Q.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Johnstone, Frank D.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
García Rodriguez, Marie Cruz
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Bates, Isabel
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Hawkins, Federico Gustavo
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
González-García, Juan Julián
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Arribas, Jose R.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Asensi-Botet, Francesc
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Otero, Ma Carmen
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Scherpbier, Henriëtte J.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Boer, Kees R.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Bohlin, Ann Britt
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Lindgren, Susanne Rosa
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Ehrnst, Anneka C.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Belfrage, Erik
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Lidman, Knut
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Lévy, Jack A.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Hainaut, Marc
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Peltier, Alexandra
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Barlow, Patricia
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Ferrazin, Antonio
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Bassetti, Dante
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
de Maria, Andrea F.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Gotta, Cristina
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Mur-Sierra, Antonío
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Paya, A.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Viñolas, M.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Carreras, Ramón C.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Coll, Oriol
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Fortuny, Clàudia
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Boguñà, Josep Maria
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Casellas-Caro, Manuel
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Canet, Yolanda
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Pardi, Giorgio
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Lanari, Marcello
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Duse, Marzia
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Statistics
Citations: 278
Authors: 58
Affiliations: 1
Identifiers
Doi:
10.1097/00002030-200012220-00013
ISSN:
02699370
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative
Participants Gender
Female