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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids
Journal of Natural Products, Volume 70, No. 6, Year 2007
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Description
Nineteen triterpenoids, possessing four different skeletons, have been reported so far from the Red Sea sponge Siphonochalina siphonella. However, no biological activity of these compounds was ever reported. This study describes the isolation of two new triterpenoids, siphonellinol C (3) and sipholenol I (4), along with several known sipholane triterpenoids from the Red Sea sponge Callyspongia (=Siphonochalina) siphonella. Allylic oxidation of the major sipholane triterpenoids, sipholenol A (1) and sipholenone A (2), by selenium dioxide afforded four C-28-oxidized derivatives. Sipholane triterpenoids along with their semisynthetic derivatives were evaluated for their cytotoxicity and effect on reversing P-glycoprotein-mediated MDR to colchicine. Sipholenol A was found to be the most potent, and it increased the sensitivity of resistant KB-C2 cells by 16 times toward colchicine. This is the first report related to reversal of cancer chemotherapy resistance using these triterpenoids. © 2007 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Jain, Sandeep
United States, Monroe
The University of Louisiana Monroe
Laphookhieo, Surat
United States, Monroe
The University of Louisiana Monroe
Shi, Zhi
United States, Queens
St. John's University
China, Guangzhou
Sun Yat-sen University
Fu, Li Wu
China, Guangzhou
Sun Yat-sen University
Akiyama, Shin Ichi
Japan, Kagoshima
Kagoshima University Graduate School of Medical and Dental Sciences
Chen, Zhe Sheng
United States, Queens
St. John's University
Youssef, D. T.A.
Egypt, Ismailia
Faculty of Pharmacy
van Soest, Rob W.M.V.
Netherlands, Amsterdam
Zoological Museum Amsterdam
El-Sayed, K. A.
United States, Monroe
The University of Louisiana Monroe
Statistics
Citations: 52
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1021/np0605889
ISSN:
01633864
Research Areas
Cancer