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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Abu Dhabi District, United Arab Emirates
Tropical Journal of Pharmaceutical Research, Volume 13, No. 5, Year 2014
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Description
Purpose: To investigate the frequency of glucose-6-phosphate dehydrogenase (G6PD) variants and their associated enzyme deficiencies among different age groups of individuals in Abu Dhabi, United Arab Emirates (UAE). Methods: A total of 15,995 patients (6302 UAE nationals and 9693 non-UAE nationals) who presented at Mafraq Hospital, Abu Dhabi, UAE between January 2006 and January 2009 were screened for G6PD deficiency using fluorescent spot test. Molecular analysis including polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), denaturing high performance liquid chromatography (DHPLC) and DNA sequencing were utilized to identify common mutations in individuals with G6PD deficiency. Results: The prevalence of G6PD deficiency among UAE nationals was 7.4% and non-UAE nationals 3.8%. UAE males showed prevalence of 11.6% while for UAE females it was 3.6%. The prevalence of G6PD deficiency among non-UAE nationals was 5 and 1.7% for males and females, respectively. The Mediterranean mutation, 563C→T, was predominant in non-UAE nationals. Conclusion: G6PD Mediterranean mutation is the most prevalent mutation underlying G6PD deficiency followed by Aures mutations in both UAE nationals and non-UAE nationals. On the other hand, Africa Awas found to be more in non-UAE compared with UAE nationals. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
Authors & Co-Authors
Amro, Saleh Ahmed Bin
Unknown Affiliation
Al Zaabi, Eiman
Unknown Affiliation
Hussain, Shakir
Unknown Affiliation
Mahmoud Aly, Amira
Unknown Affiliation
Salman Baqir, Huda
Unknown Affiliation
Abdel-Hamid, A. Z.
Unknown Affiliation
Saghir, Sultan Ayesh Mohammed
Unknown Affiliation
Yusoff, Narazah Mohammed
Unknown Affiliation
Statistics
Citations: 9
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.4314/tjpr.v13i5.12
ISSN:
15965996
e-ISSN:
15969827
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Benin
Nigeria
Participants Gender
Female