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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma
PLoS Genetics, Volume 10, No. 3, Article e1004089, Year 2014
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Description
Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = -0.045 mm, P = 8.17×10-9). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45×10-9; 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions. © 2014 Nongpiur et al.
Authors & Co-Authors
Nongpiur, Monisha Esther
Unknown Affiliation
Khor, Chiea Chuen
Unknown Affiliation
Jia, Hongyan
Unknown Affiliation
Cornes, Belinda K.
Unknown Affiliation
Chen, Lijia
Unknown Affiliation
Qiao, Chunyan
Unknown Affiliation
Nair, K. Saidas
Unknown Affiliation
Cheng, Ching Yu
Unknown Affiliation
Xu, Liang
Unknown Affiliation
George, Ronnie Jacob
Unknown Affiliation
Tan, Do
Unknown Affiliation
Abu-Amero, Khaled Khader
Unknown Affiliation
Perera, Shamira A.
Unknown Affiliation
Ozaki, Mineo
Unknown Affiliation
Mizoguchi, Takanori
Unknown Affiliation
Kurimoto, Yasuo
Unknown Affiliation
Low, Sancy
Unknown Affiliation
Tajudin, Liza Sharmini A.
Unknown Affiliation
Ho, Ching Lin
Unknown Affiliation
Tham, Clement C.Y.
Unknown Affiliation
Soto, Ileana
Unknown Affiliation
Chew, Paul Tec Kwan
Unknown Affiliation
Wong, Hong Tym
Unknown Affiliation
Shantha, Balekudaru
Unknown Affiliation
Kuroda, Masako
Unknown Affiliation
Osman, Essam A.
Unknown Affiliation
Tang, Guangxian
Unknown Affiliation
Fan, Sujie
Unknown Affiliation
Meng, Hailin
Unknown Affiliation
Wang, Hua
Unknown Affiliation
Feng, Bo
Unknown Affiliation
Yong, Victor H.K.
Unknown Affiliation
Ting, Serena M.L.
Unknown Affiliation
Li, Yang
Unknown Affiliation
Wang, Yaxing
Unknown Affiliation
Li, Zheng
Unknown Affiliation
Lavanya, Raghavan
Unknown Affiliation
Wu, Renyi
Unknown Affiliation
Zheng, Yingfeng
Unknown Affiliation
Su, Daniel H.
Unknown Affiliation
Loon, Seng Chee
Unknown Affiliation
Allingham, Robert Rand
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Hauser, Michael Arthur
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Soumittra, Nagaswamy
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Ramprasad, Vedam L.
Unknown Affiliation
Waseem, Naushin
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Azhany, Yaakub
Unknown Affiliation
Chia, Kee Seng
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Kumaramanickavel, Govindasamy
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Wong, Tina T.
Unknown Affiliation
How, Alicia C.
Unknown Affiliation
Chau, Tran Nguyen Bich
Unknown Affiliation
Simmons, Cameron Paul
Unknown Affiliation
Bei, Jin Xin
Unknown Affiliation
Zeng, Yixin
Unknown Affiliation
Bhattacharya, Shomi Shanker
Unknown Affiliation
Zhang, Mingzhi
Unknown Affiliation
Tan, Donald T.H.
Unknown Affiliation
Teo, Yik Ying
Unknown Affiliation
Al-Obeidan, Saleh Ali
Unknown Affiliation
Hon, Do Nhu
Unknown Affiliation
Tai, E. Shyong
Unknown Affiliation
Saw, Seang Mei
Unknown Affiliation
Foster, Paul J.
Unknown Affiliation
Vijaya, Lingam
Unknown Affiliation
Jonas, Jost Bruno
Unknown Affiliation
Wong, Tienyin
Unknown Affiliation
John, Simon W.M.
Unknown Affiliation
Pang, Chi Pui
Unknown Affiliation
Vithana, Eranga N.
Unknown Affiliation
Wang, Ningli
Unknown Affiliation
Aung, Tin
Unknown Affiliation
Statistics
Citations: 75
Authors: 72
Affiliations: 26
Identifiers
Doi:
10.1371/journal.pgen.1004089
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Case-Control Study