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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Case-fatality ratio of bacterial meningitis in the African meningitis belt: We can do better
Vaccine, Volume 25, No. SUPPL. 1, Year 2007
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Description
In the African meningitis belt, reported case-fatality ratio (CFR) for meningitis are usually calculated on the basis of presumed cases. We reviewed 3509 presumed cases of bacterial meningitis reported in Niger for which a cerebrospinal fluid (CSF) sample had been tested later at the reference laboratory. The main aetiologies were Neisseria meningitidis (1496 cases), Streptococcus pneumoniae (303 cases) and Haemophilus influenzae (105 cases). The CFR of meningococcal meningitis was lower for serogroup A (5.5%) than for serogroups X (12%) and W135 (12.7%). With a CFR of 49.8%, pneumococcal meningitis, albeit representing only 20.7% of confirmed cases, accounted for 50% of the deaths. The disease burden of pneumococcal meningitis must be better taken into consideration in the future. As most treatments are presumptive, there is a urgent need for an easy-to-administer, cheap first-line treatment effective on N. meningitidis as well as on S. pneumoniae and H. influenzae that would replace the single-dose oily chloramphenicol treatment which is the most frequent treatment administered today, independent of microbial aetiology and season. The development of diagnostic tools really suitable for remote health facilities also is an urgent challenge. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Boisier, Pascal
Niger, Niamey
Centre de Recherche Medicale et Sanitaire Niamey
Maïnassara, Halima Boubacar
Niger, Niamey
Centre de Recherche Medicale et Sanitaire Niamey
Sidikou, Fati
Niger, Niamey
Centre de Recherche Medicale et Sanitaire Niamey
Djibo, Saacou
Niger, Niamey
Centre de Recherche Medicale et Sanitaire Niamey
Kairo, Kiari Kaka
Niger
Ministère de la Santé
Chanteau, Suzanne
Niger, Niamey
Centre de Recherche Medicale et Sanitaire Niamey
Statistics
Citations: 46
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.vaccine.2007.04.036
ISSN:
0264410X
Study Locations
Niger