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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Reduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1
Oncogene, Volume 24, No. 51, Year 2005
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Description
Understanding cell dynamics in animal models have implications for therapeutic strategies elaborated against leukemia in human. Quantification of the cell turnover in closely related primate systems is particularly important for rare and aggressive forms of human cancers, such as adult T-cell leukemia. For this purpose, we have measured the death and proliferation rates of the CD4+ T lymphocyte population in squirrel monkeys (Saimiri sciureus) infected by human T-lymphotropic virus type 1 (HTLV-1). The kinetics of in vivo bromodeoxyuridine labeling revealed no modulation of the cell turnover in HTLV-1-infected monkeys with normal CD4 cell counts. In contrast, a substantial decrease in the proliferation rate of the CD4+ T population was observed in lymphocytic monkeys (e.g. characterized by excessive proportions of CD4+ T lymphocytes and by the presence of abnormal flower-like cells). Unexpectedly, onset of HTLV-associated leukemia thus occurs in the absence of increased CD4+ T-cell proliferation. This dynamics significantly differs from the generalized activation of the T-cell turnover induced by other primate lymphotropic viruses like HIV and SIV. © 2005 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Héraud, Jean Michel
French Guiana, Cayenne
Institut Pasteur de la Guyane
Asquith, Becca E.
United Kingdom, London
Imperial College London School of Medicine
Bangham, Charles R.M.
United Kingdom, London
Imperial College London School of Medicine
Mérien, Fabrice
French Guiana, Cayenne
Institut Pasteur de la Guyane
Mortreux, Franck
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Wattel, Éric
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Burny, Arséne
Belgium, Liege
Université de Liège
Kazanji, Mirdad
French Guiana, Cayenne
Institut Pasteur de la Guyane
Statistics
Citations: 12
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1038/sj.onc.1208896
ISSN:
14765594
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study