Valvular involvement in granulomatosis with polyangiitis: Case report and systematic review of literature
Echocardiography, Volume 35, No. 9, Year 2018
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Background: Granulomatosis with polyangiitis (GPA) is a systemic inflammatory condition; however, patients with GPA rarely experience endocardial valve lesions. Methods: We report a GPA case with tricuspid valve destruction together with a systematic review to highlight the characteristics of all previously reported GPA cases with valvular involvement. Results: Among 36 cases included, the aortic valve was involved in 15 (41.7%) cases while the mitral valve was involved in 9 (25%) subjects. Combined lesion of both aortic and mitral valves was reported in 9 (25%) patients. Conclusion: We recommend routine echocardiography examination to rule out any cardiac valve lesion once GPA is suspected.