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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Laboratory reference values for healthy adults from southern Tanzania
Tropical Medicine and International Health, Volume 13, No. 5, Year 2008
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Description
Objectives: To define and discuss reference ranges for commonly determined laboratory parameters in healthy adults from southern Tanzania. Methods: A population-based sample of adult volunteers from Mbeya, Tanzania, who were not HIV positive or showing signs and symptoms of other diseases, participated in this study. We enrolled 145 women and 156 men between 19 and 48 years of age to determine clinical chemistry (CC), haematology and lymphocyte immunophenotyping (LIP) parameters using standard laboratory methods. Medians and nonparametric 95% reference ranges for each parameter were determined and compared with reference ranges from the USA, Europe and from other African countries. Results: Agreement with ranges from developed countries was poor: for CC values the average concordance was 80.9% and 86.7% with values from two developed countries. Haematology ranges from the USA classified 86.3% of values correctly, whereas ranges from three different sub-Saharan Africa (SSA) sites classified between 82.5% and 94.5% of values correctly. The agreement of LIP reference ranges was 87.5% with values determined in Germany but between 91.7% and 95.8% compared with values determined at other sites in SSA. Conclusion: Clinical reference ranges determined in developed countries are inadequate for use in SSA. Laboratories in this region should either define their own or use values determined under similar conditions. The ranges reported here are more appropriate for use in SSA than ranges determined in developed countries. © 2008 Blackwell Publishing Ltd.
Authors & Co-Authors
Saathoff, Elmar
Germany, Munich
Klinikum Der Universität München
Schneider, Philine
Germany, Munich
Klinikum Der Universität München
Kleinfeldt, Vera
Tanzania
Mbeya Medical Research Programme
Geis, Steffen
Germany, Munich
Klinikum Der Universität München
Tanzania
Mbeya Medical Research Programme
Haule, Dennis
Tanzania
Mbeya Medical Research Programme
Maboko, Leonard L.
Tanzania
Mbeya Medical Research Programme
Samky, Eleuter
Tanzania, Tanga
Regional Medical Office
Souza, Mark De
United States, Rockville
Hjf
Robb, Merlin Lee
United States, Silver Spring
Walter Reed Army Institute of Research
Höelscher, Michael
Germany, Munich
Klinikum Der Universität München
Statistics
Citations: 136
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2008.02047.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Tanzania
Participants Gender
Male
Female