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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The international research on infant supplementation initiative
Journal of Nutrition, Volume 135, No. 3, Year 2005
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Description
The International Research on Infant Supplementation trials emerged as an attempt to develop a credible evidence base to guide policy decision making in this area. The fact that infant diets in developing country settings are more often deficient in multiple micronutrients rather than in single nutrients and/or energy was increasingly recognized during the 1990s. The concept of a "foodlet," a crushable hybrid between a tablet and a food that is water dispersible, was developed at the first IRIS meeting in Rio de Janeiro in 1999, Trials were performed in 4 countries: Indonesia, Peru, South Africa, and Vietnam. Four different formulations of foodlets were tested: a daily placebo supplement, a daily iron supplement, a daily multiple micronutrient supplement, and a weekly multiple micronutrient supplement with a placebo on the other 6 d. The multiple micronutrient foodlets contained adequate daily intakes of 13 micronutrients considered most likely to be inadequate in infant diets. The foodlets were produced in Peru and distributed to all 4 of the country study sites. The methods used in the efficacy trials were standardized across countries, and the trials were carried out in infants 6-11 mo of age for 6 mo. Anthropometry was measured monthly and morbidity checked daily. Blood samples were collected at baseline and at the end of the trial. The data and the biological samples collected in each country were analyzed centrally. The results of this remarkable international collaboration are encouraging and, hopefully, will spur the development of programs in this area of nutrition interventions. © 2005 American Society for Nutritional Sciences.
Authors & Co-Authors
Groß, Rainer
United States, New York
Unicef
Benadé, Ambrose J.Spinnler
South Africa, Tygerberg
South African Medical Research Council
Lopez, Guillermo
Peru, Lima
Universidad Nacional Agraria la Molina
Statistics
Citations: 15
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1093/jn/135.3.628s
ISSN:
00223166
Research Areas
Environmental
Food Security
Health System And Policy
Maternal And Child Health
Study Locations
South Africa