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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
New insights into the biological properties of Crocus sativus L.: Chemical modifications, human monoamine oxidases inhibition and molecular modeling studies
European Journal of Medicinal Chemistry, Volume 82, Year 2014
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Description
Although there are clinical trials and in vivo studies in literature regarding the anxiolytic and antidepressant activities of the components of Crocus sativus L., their effects on the human monoamine oxidases (hMAO-A and hMAO-B), enzymes which are involved in mental disorders and neurodegenerative diseases, have not yet been investigated. We have thus examined the hMAO inhibitory activities of crocin and safranal (the most important active principles in saffron) and, subsequently, designed a series of safranal derivatives to evaluate which chemical modifications confer enhanced inhibition of the hMAO isoforms. Docking simulations were performed in order to identify key molecular recognitions of these inhibitors with both isoforms of hMAO. In this regard, different mechanisms of action were revealed. This study concludes that safranal and crocin represent useful leads for the discovery of novel hMAO inhibitors for the clinical management of psychiatric and neurodegenerative disorders. © 2014 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
de Monte, Celeste
Italy, Rome
Sapienza Università Di Roma
Carradori, Simone
Italy, Rome
Sapienza Università Di Roma
Chimenti, Paola
Italy, Rome
Sapienza Università Di Roma
Secci, Daniela
Italy, Rome
Sapienza Università Di Roma
Mannina, Luísa
Italy, Rome
Sapienza Università Di Roma
Italy, Rome
Consiglio Nazionale Delle Ricerche
Alcaro, Francesca
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Petzer, Anél
South Africa, Potchefstroom
North-west University
N'Da, Clarina I.
South Africa, Potchefstroom
North-west University
Gidaro, Maria Concetta
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Costa, Giosuè
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Alcaro, Stefano
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Petzer, Jacobus P.
South Africa, Potchefstroom
North-west University
Statistics
Citations: 55
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2014.05.048
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Mental Health