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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats
Journal of Ethnopharmacology, Volume 125, No. 1, Year 2009
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Description
Many cardiovascular diseases are associated with an increase in blood platelet activity. In Morocco, parsley (Petroselinum crispum, Apiaceae) is one of the medicinal herbs used to treat cardiovascular diseases such as arterial hypertension. In this study, crude aqueous extract (CAE) of parsley was evaluated for its anti-platelet activity in experimental animals on platelet aggregation in vitro and ex vivo; and on bleeding time in vivo. The in vitro aggregation was monitored after pre-incubation of platelets with CAE. The bleeding time and ex vivo aggregation were performed after oral treatment. CAE inhibited dose dependently platelet aggregation in vitro induced by thrombin, ADP, collagen and epinephrine. The oral administration of CAE (3 g/kg) inhibited significantly (p < 0.001) platelet aggregation ex vivo and prolonged bleeding time (p < 0.001) without changes in the platelet amount. The prolongation of bleeding time by CAE may be attributed to the observed inhibition of platelet aggregation. These effects could be related in part to the polyphenolic compounds present in the extract. These results support the hypothesis that the dietary intake of parsley may be benefit in the normalization of platelet hyperactivation, in the nutritional prevention of cardiovascular diseases and are potentially interesting in the development of new prevention strategies. © 2009.
Authors & Co-Authors
Gadi, Dounia
Morocco, Oujda
Université Mohammed Premier Oujda
Bnouham, Mohamed
Morocco, Oujda
Université Mohammed Premier Oujda
Aziz, Mohammed
Morocco, Oujda
Université Mohammed Premier Oujda
Ziyyat, Abderrahim
Morocco, Oujda
Université Mohammed Premier Oujda
Legssyer, Abdelkhaleq
Morocco, Oujda
Université Mohammed Premier Oujda
Legrand, Chantal
France, Paris
Hôpital Saint-louis
Lafeve, Françoise Fauvel
France, Paris
Hôpital Saint-louis
Mekhfi, Hassane
Morocco, Oujda
Université Mohammed Premier Oujda
Statistics
Citations: 83
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.jep.2009.05.014
ISSN:
03788741
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Locations
Morocco