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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased levels of inflammatory mediators in children with severe Plasmodium falciparum malaria with respiratory distress
Journal of Infectious Diseases, Volume 194, No. 10, Year 2006
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Description
Background. Respiratory distress (RD), a symptom of underlying metabolic acidosis, has been identified as a major risk factor for mortality in children with severe malaria in Africa, yet the molecular mediators involved in the pathogenesis of RD have not been identified. Methods. We studied circulating levels of mediators of inflammation-including the cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-10; the chemokines macrophage inflammatory protein (MIP)-1α, MIP-1β, and IL-8; and the immune activation marker neopterin-in children with RD, severe malarial anemia (SMA), cerebral malaria (CM), and uncomplicated malaria (UM). Results. Children with RD had significantly higher plasma levels of TNF-α, IL-10, and neopterin and a significantly higher TNF-α:IL-10 ratio than those without RD. In addition, the results demonstrated that, relative to UM, CM was associated with increased levels of TNF-α and decreased levels of MIP-1α, whereas SMA was associated with decreased levels of IL-10. Circulating levels of neopterin were inversely correlated with hemoglobin, whereas levels of MIP-1β were positively correlated with parasitemia. Conclusions. We conclude that distinct clinical presentations of severe malaria are associated with specific patterns of inflammatory mediators. In particular, we show, to our knowledge for the first time, that patients with malaria and RD have a strong and unbalanced proinflammatory response that may be involved in the pathogenesis of the underlying metabolic acidosis. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Awandare, Gordon Akanzuwine
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Goka, Bamenla Quarm
Ghana, Accra
University of Ghana
Boeuf, Philippe S.
France, Paris
Institut Pasteur, Paris
Tetteh, John
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Kurtzhals, J. A.L.
Denmark, Copenhagen
Copenhagen University Hospital
Behr, Charlotte
France, Paris
Institut Pasteur, Paris
Akanmori, Bartholomew Dicky
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Statistics
Citations: 87
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1086/508547
ISSN:
00221899
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases