Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry: Baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study
BMC Infectious Diseases, Volume 20, No. 1, Article 473, Year 2020
Notification
URL copied to clipboard!
Description
Background: People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection with HIV contributes to the development of CVD independent of traditional risk factors, with endothelial dysfunction being the central physiological mechanism. While HIV-related mortality is declining due to antiretroviral treatment (ART), the number of deaths due to CVD is rising in South Africa-the country with the highest number of PLHIV and the world's largest ART programme. The EndoAfrica study was developed to determine whether HIV infection and ART are associated with cardiovascular risk markers and changes in vascular structure and function over 18 months in adults from different provinces of South Africa. This paper describes the rationale, methodology and baseline cohort profile of the EndoAfrica study conducted in the North West Province, South Africa. Methods: In this case-control study, conducted between August 2017 and June 2018, 382 volunteers of African descent (276 women; 106 men), comprising of 278 HIV infected and 104 HIV free individuals were included. We measured health behaviours, a detailed cardiovascular profile, and performed biomarker analyses. We compared baseline characteristics, blood pressure, vascular function and biochemical markers between those infected and HIV free. Results: At baseline, the HIV infected participants were older (43 vs 39 years), less were employed (21% vs 40%), less had a tertiary education (7% vs 16%) and their body mass index was lower (26 vs 29 kg/m2) than that of the HIV free participants. While the cardiovascular profile, flow-mediated dilation and pulse wave velocity did not differ, glycated haemoglobin was lower (p = 0.017) and total cholesterol, high density lipoprotein cholesterol, triglycerides, gamma-glutamyltransferase and tobacco use were higher (all p < 0.047) in PLHIV. Conclusion: Despite PLHIV being older, preliminary cross-sectional analysis suggests that PLHIV being treated with ART do not have poorer endothelial or vascular function compared to the HIV free participants. More detailed analyses on the baseline and follow-up data will provide further clarity regarding the cardiovascular profile of South Africans living with HIV. © 2020 The Author(s).
Authors & Co-Authors
Fourie, Carla M. T. Maria Theresia
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Botha, Shani
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Smith, Wayne
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Schutte, Aletta E.
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Australia, Sydney
George Institute for Global Health
Breet, Yolandi
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
M.c Mels, Catharina
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Gafane-Matemane, Lebo Francina
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Lammertyn, Leandi
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Uys, Lisa
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Burger, Adele
South Africa, Potchefstroom
North-west University
South Africa, Tygerberg
South African Medical Research Council
Joseph, Jitcy Saji
South Africa, Johannesburg
National Centre for Occupational Health
Goswami, Nandu
Austria, Graz
Medizinische Universität Graz
De Boever, Patrick
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Belgium, Hasselt
Universiteit Hasselt
Belgium, Antwerpen
Universiteit Antwerpen
Strijdom, Hans
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 9
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1186/s12879-020-05173-6
ISSN:
14712334
Research Areas
Infectious Diseases
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
South Africa
Participants Gender
Male
Female