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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Increasing evidence for a human breast carcinoma virus with geographic differences
Cancer, Volume 101, No. 4, Year 2004
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Description
BACKGROUND. An early immunologic study suggesting that a virus similar to the mouse mammary tumor virus (MMTV) was associated highly with breast carcinoma in Tunisian patients, compared with patients in the United States, led the authors to examine different breast carcinoma populations by using more current molecular techniques. METHODS. Thirty-nine paraffin blocks were selected for sequencing of the 250-base pair segment of the MMTV from patients with breast carcinoma who were seen and treated at the Institut Salah Azaiz in Tunisia. Fifteen of those blocks were examined under code by a second laboratory, which used a different methodology and was blinded to the results of the first laboratory, and 14 blocks were analyzed successfully. RESULTS. The comparison of Tunisian patients and patients from other countries clearly showed a significantly higher proportion of tumors with MMTV-like sequences in the Tunisian series of patients. There was complete reproducibility of data between the two laboratories. Using the results from the first laboratory and similar studies from the literature, detection of the MMTV-like env gene sequence showed an important geographic pattern with a significantly higher percentage of positive patients with breast carcinoma in Tunisia (74%) compared with patients with breast carcinoma in the United States (36%), Italy (38%), Australia (42%), Argentina (31%), and Vietnam (0.8%) CONCLUSIONS. The findings provided increased evidence for a human breast carcinoma virus with geographic differences in prevalence. The geographic differences were compatible with studies of MMTV in wild mice; thus, the data were plausible biologically. © 2004 American Cancer Society.
Authors & Co-Authors
Levine, Paul H.
United States, Washington, D.c.
Milken Institute School of Public Health
Pogo, Beatriz G.T.
United States, New York
Icahn School of Medicine at Mount Sinai
Klouj, Afifa
United States, Washington, D.c.
Milken Institute School of Public Health
Coronel, Stephanie
United States, Omaha
Creighton University
Woodson, Karen
United States, Rockville
National Cancer Institute Nci
Melana, Stella M.
United States, New York
Icahn School of Medicine at Mount Sinai
Mourali, Nejib
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Holland, James F.W.
United States, New York
Icahn School of Medicine at Mount Sinai
Statistics
Citations: 91
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1002/cncr.20436
ISSN:
0008543X
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Tunisia