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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evidence of Dengue Virus Transmission and Factors Associated with the Presence of Anti-Dengue Virus Antibodies in Humans in Three Major Towns in Cameroon
PLoS Neglected Tropical Diseases, Volume 8, No. 7, Article e2950, Year 2014
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Description
Background:Dengue is not well documented in Africa. In Cameroon, data are scarce, but dengue infection has been confirmed in humans. We conducted a study to document risk factors associated with anti-dengue virus Immunoglobulin G seropositivity in humans in three major towns in Cameroon.Methodology/Principal Findings:A cross sectional survey was conducted in Douala, Garoua and Yaounde, using a random cluster sampling design. Participants underwent a standardized interview and were blood sampled. Environmental and housing characteristics were recorded. Randomized houses were prospected to record all water containers, and immature stages of Aedes mosquitoes were collected. Sera were screened for anti-dengue virus IgG and IgM antibodies. Risk factors of seropositivity were tested using logistic regression methods with random effects.Anti-dengue IgG were found from 61.4% of sera in Douala (n = 699), 24.2% in Garoua (n = 728) and 9.8% in Yaounde (n = 603). IgM were found from 0.3% of Douala samples, 0.1% of Garoua samples and 0.0% of Yaounde samples. Seroneutralization on randomly selected IgG positive sera showed that 72% (n = 100) in Douala, 80% (n = 94) in Garoua and 77% (n = 66) in Yaounde had antibodies specific for dengue virus serotype 2 (DENV-2).Age, temporary house walls materials, having water-storage containers, old tires or toilets in the yard, having no TV, having no air conditioning and having travelled at least once outside the city were independently associated with anti-dengue IgG positivity in Douala. Age, having uncovered water containers, having no TV, not being born in Garoua and not breeding pigs were significant risk factors in Garoua. Recent history of malaria, having banana trees and stagnant water in the yard were independent risk factors in Yaounde.Conclusion/Significance:In this survey, most identified risk factors of dengue were related to housing conditions. Poverty and underdevelopment are central to the dengue epidemiology in Cameroon. © 2014 Demanou et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4091864/bin/pntd.0002950.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4091864/bin/pntd.0002950.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4091864/bin/pntd.0002950.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4091864/bin/pntd.0002950.s004.doc
Authors & Co-Authors
Demanou, Maurice
Cameroon, Yaounde
Centre Pasteur du Cameroun
Pouillot, R.
Cameroon, Yaounde
Centre Pasteur du Cameroun
Grandadam, Marc
Laos, Vientiane
Institut Pasteur du Laos
Boisier, Pascal
Cameroon, Yaounde
Centre Pasteur du Cameroun
Kamgang, Basile
Central African Republic, Bangui
Institut Pasteur de Bangui
Hervé, Jean Pierre
France, Montpellier
Ird Centre de Montpellier
Rogier, Christophe
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rousset, Dominique
Cameroon, Yaounde
Centre Pasteur du Cameroun
French Guiana, Cayenne
Institut Pasteur de la Guyane
Paupy, Christophe
France, Montpellier
Ird Centre de Montpellier
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Statistics
Citations: 51
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pntd.0002950
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Cameroon