Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Taxonomy of the Trichophyton mentagrophytes/T. interdigitale Species Complex Harboring the Highly Virulent, Multiresistant Genotype T. indotineae
Mycopathologia, Volume 186, No. 3, Year 2021
Notification
URL copied to clipboard!
Description
A severe outbreak of highly virulent and multi-resistant dermatophytosis by species in the Trichophyton mentagrophytes/T. interdigitale complex is ongoing in India. The correct identity of the etiologic agent is a much-debated issue. In order to define species limits, a taxonomic study was undertaken combining molecular, morphological, and physiological characteristics as evidence of classification. Molecular characteristics show that T. mentagrophytes s. str. and T. interdigitale s. str. can be distinguished with difficulty from each other, but are unambiguously different from the Indian genotype, T. indotineae by sequences of the HMG gene. The entities were confirmed by multilocus analysis using tanglegrams. Phenotypic characters of morphology and physiology are not diagnostic, but statistically significant differences are observed between the molecular siblings. These properties may be drivers of separate evolutionary trends. Trichophyton mentagrophytes represents the ancestral, homothallic cloud of genotypes with a probable geophilic lifestyle, while T. indotineae and T. interdigitale behave as anthropophilic, clonal offshoots. The origin of T. indotineae, which currently causes a significant public health problem, is zoonotic, and its emergence is likely due to widespread misuse of antifungals. © 2021, The Author(s).
Authors & Co-Authors
Ahmed, Sarah A.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Chowdhary, Anuradha K.
India, New Delhi
University of Delhi
Nenoff, Pietro
Germany, Mölbis
Laboratory for Medical Microbiology
Uhrlass, Silke
Germany, Mölbis
Laboratory for Medical Microbiology
Verma, Shyam Bhanushankar
Unknown Affiliation
Meis, Jacques F.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Kandemir, Hazal
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Turkey, Adana
Çukurova Üniversitesi
Kang, Yingqian
China, Beijing
Ministry of Education of the People's Republic of China
de Hoog, Gerrits Sybren
China, Beijing
Ministry of Education of the People's Republic of China
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Statistics
Citations: 66
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1007/s11046-021-00544-2
ISSN:
0301486X
Research Areas
Genetics And Genomics
Infectious Diseases