Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Transmission of onchocerciasis in Wadelai focus of northwestern Uganda has been interrupted and the disease eliminated
Journal of Parasitology Research, Volume 2012, Article 748540, Year 2012
Notification
URL copied to clipboard!
Description
Wadelai, an isolated focus for onchocerciasis in northwest Uganda, was selected for piloting an onchocerciasis elimination strategy that was ultimately the precursor for countrywide onchocerciasis elimination policy. The Wadelai focus strategy was to increase ivermectin treatments from annual to semiannual frequency and expand geographic area in order to include communities with nodule rate of less than 20%. These communities had not been covered by the previous policy that sought to control onchocerciasis only as a public health problem. From 2006 to 2010, Wadelai program successfully attained ultimate treatment goal (UTG), treatment coverage of ≥90%, despite expanding from 19 to 34 communities and from 5,600 annual treatments to over 29,000 semiannual treatments. Evaluations in 2009 showed no microfilaria in skin snips of over 500 persons examined, and only 1 of 3011 children was IgG4 antibody positive to the OV16 recombinant antigen. No Simulium vectors were found, and their disappearance could have sped up interruption of transmission. Although twice-per-year treatment had an unclear role in interruption of transmission, the experience demonstrated that twice-per-year treatment is feasible in the Ugandan setting. The monitoring data support the conclusion that onchocerciasis has been eliminated from the Wadelai focus of Uganda. © 2012 Moses N. Katabarwa et al.
Authors & Co-Authors
Katabarwa, Moses N.
United States, Atlanta
Emory University
Walsh, Frank
Unknown Affiliation
Habomugisha, Peace
Uganda, Kampala
Carter Center Uganda
Lakwo, Thomson L.
Uganda, Kampala
Uganda Ministry of Health
Agunyo, Stella
Uganda, Kampala
Carter Center Uganda
Oguttu, David Were
Uganda, Kampala
Uganda Ministry of Health
Unnasch, Thomas Raymond
United States, Tampa
University of South Florida Health
Unoba, Dickson
Uganda
Nebbi District Health Services
Byamukama, Edson
Uganda, Kampala
Carter Center Uganda
Tukesiga, Ephraim
Uganda
Kabarole District Health Services
Ndyomugyenyi, Richard
Uganda, Kampala
Uganda Ministry of Health
Richards, Frank O.
United States, Atlanta
Emory University
Statistics
Citations: 74
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1155/2012/748540
ISSN:
20900023
e-ISSN:
20900031
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Uganda