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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Hemophagocytic syndrome after hematopoietic stem cell transplantation: A prospective observational study
International Journal of Hematology, Volume 89, No. 3, Year 2009
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Description
The aim of this prospective observational study was to evaluate the incidence of hemophagocytic syndrome (HPS) after hematopoietic stem cell transplantation (HSCT). Between July 2006 and December 2007, all patients who received a HSCT in our institution were included in this study. All the following criteria were needed for the diagnosis of HPS: sustained fever over 7 days; cytopenia (neutropenia and/or thrombocytopenia); presence of more than 3% mature macrophages in bone marrow; hyperferritinaemia (>1,000 ng/mL). During this study, 171 patients received a HSCT (68 allogeneic and 103 autologous). The median age was 32 years (3-62). We observed six cases of HPS (6/68; 8.8%) after allogeneic stem cell transplantation (ASCT): one case of EBV-related HPS, two cases of CMV-related HPS, and three cases with no evidence of bacterial, fungal or viral infections. We observed only one case of CMV-related HPS (1/103; 0.9%) after autologous stem cell transplantation. Four patients died despite aggressive supportive care. To our knowledge, this is the first prospective observational study conducted with the aim to evaluate the incidence of HPS after HSCT. This study provides a relatively high incidence of HPS after ASCT. When sustained fever with progressive cytopenia and hyperferritinaemia are observed, HPS should be suspected, and bone marrow aspirate considered. The rapid diagnosis of HPS and the early initiation of an appropriate treatment are essential for patient management. © 2009 The Japanese Society of Hematology.
Authors & Co-Authors
Abdelkefi, Abderrahman
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Jamil, Wassim Ben
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Torjman, Lamia
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Ladeb, Saloua
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Ksouri, Habib
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Lakhal, Amel
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Ben Hassen, Assia
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Abdeladhim, Abdeladhim Ben
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Othman, Tarek Ben
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Statistics
Citations: 57
Authors: 9
Affiliations: 1
Identifiers
Doi:
10.1007/s12185-009-0261-1
Research Areas
Health System And Policy
Study Design
Cohort Study