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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial
Journal of Infectious Diseases, Volume 206, No. 12, Year 2012
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Description
The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HD-2 (odds ratio [OR], 2.39; P =. 005) and greater Escherichia coli bactericidal activity (OR, 1.22; P =. 01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P =. 02) and may be a biomarker for HIV-1 acquisition. © 2012 The Author.
Authors & Co-Authors
Dezzutti, Charlene S.
United States, Pittsburgh
Magee-womens Research Institute
Richardson, Barbra Ann
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Marrazzo, Jeanne Marisa
United States, Seattle
University of Washington
Tugetman, Jessica
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Ramjee, Gita A.
South Africa, Tygerberg
South African Medical Research Council
Taha, Taha E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Chirenje, Zvavahera Mike
Zimbabwe, Harare
University of Zimbabwe
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Hillier, Sharon L.
United States, Pittsburgh
Magee-womens Research Institute
Herold, Betsy C.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 21
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1093/infdis/jis555
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Case-Control Study
Participants Gender
Female